Correction: Long noncoding RNA MARL regulates antiviral responses through suppression miR-122-dependent MAVS downregulation in lower vertebrates

Abstract

Figures

G](#ppat.1013059.g001), which is a duplicate of the left-hand MARL panel of Fig 7E; a revised [Fig 1](#ppat.1013059.g001) is provided in which this panel is replaced with the correct image from the original experiment, which has been verified in the investigation by Shanghai Ocean University.

Full text

Following publication of this article [1], questions were raised about similarity between this work and other studies by the same group, including about similarities in data reported for efficiency of miRNA knockdown by different oligonucleotide inhibitors. An investigation by Shanghai Ocean University found that the data reported in [1] are reliable and valid, and that similarities may have arisen because screening to identify functional molecules was carried out on a large scale simultaneously, with strict standards and thresholds set for taking forward further investigation of specific molecules.

The PLOS Pathogens Editors consider the above issue resolved, and issue this Correction to address additional items as follows:

Contrary to the Data Availability statement accompanying this article [1], the complete underlying data were not made available at the time of publication. The available individual-level quantitative data are provided in S1 File with this notice. Raw qPCR data are no longer available. The available underlying image data are provided in S2 File with this notice.

There is an error in Fig 1. The incorrect image was used in the left-hand si-Ctrl panel of Fig 1G, which is a duplicate of the left-hand MARL panel of Fig 7E; a revised Fig 1 is provided in which this panel is replaced with the correct image from the original experiment, which has been verified in the investigation by Shanghai Ocean University.

There is an error in Fig 6. The Tubulin western blot panel in Fig 6D is incorrect and is a duplicate of the Tubulin panel in Figure 5F of [2]. A revised Fig 6 is provided in which the Tubulin panel is replaced with the correct western blot image from the original experiment, which has been verified in the investigation by Shanghai Ocean University.

Editorial assessment of the underlying blot images identified that the published western blot panels in Fig 8E show tubulin loading control bands taken from different lanes compared to the corresponding MAVS bands. The corresponding author stated that the control and experimental blots were generated from different gels that differed in sample loading order.

The ethical approval document issued by the Research Ethics Committee of Shanghai Ocean University has been provided for editorial review, and a representative of Shanghai Ocean University has confirmed that the procedures reported in [1] are in accordance with this ethical approval and conducted within its period of validity.

Supporting information

S1 FileIndividual-level quantitative data underlying charts and graphs.(ZIP)

S2 FileUnderlying image data for Figures 1-9, S1, and S4.(ZIP)