# Headaches, Heart Block, and a Heart Tumor: Unusual Presentation of Malignant Melanoma

**Authors:** Sahar Sohrabian, Ramona Mehrinfar-Zadeh

PMC · DOI: 10.7759/cureus.80235 · Cureus · 2025-03-07

## TL;DR

A rare case of malignant melanoma spreading to the heart presented with unusual symptoms like headaches and heart block.

## Contribution

Highlights the importance of considering metastatic melanoma in cardiac tumor diagnoses due to its unique presentation.

## Key findings

- Malignant melanoma can metastasize to the heart with non-specific symptoms like headaches and heart block.
- Cardiac tumors may be misdiagnosed initially due to non-specific symptoms and require advanced imaging for confirmation.
- Prognosis for metastatic melanoma to the heart is poor despite various treatment approaches.

## Abstract

Cardiac tumors may range from benign primary cardiac masses to malignant metastatic tumors. The constellation of systemic symptoms and presenting findings in metastatic cardiac tumors may be non-specific and may lead to non-cardiac testing before the diagnosis is confirmed with advanced cardiac imaging. We present a case of malignant melanoma with metastatic disease to the heart presenting with headaches, altered mental status, and complete heart block. A detailed history and dermatologic exam should be pursued in any case of cardiac tumor, as metastatic melanoma has a predilection for cardiac involvement. The prognosis remains poor independent of chemotherapy, immunotherapy, and surgical resection, especially with a higher burden of metastatic disease.

## Linked entities

- **Diseases:** malignant melanoma (MONDO:0005105), heart tumor (MONDO:0021209), complete heart block (MONDO:0000468)

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11972931/full.md

## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC11972931/full.md

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Source: https://tomesphere.com/paper/PMC11972931