# A Rare Case of Concurrent Primary Biliary Cholangitis and Sarcoidosis

**Authors:** Robert S Gordon, Mrudula Bandaru, Laxmikausthubha Yaratha, Marie L Borum, Mamoun Younes

PMC · DOI: 10.7759/cureus.80228 · Cureus · 2025-03-07

## TL;DR

This paper reports a rare case where a patient had both primary biliary cholangitis and sarcoidosis, highlighting the importance of accurate diagnosis for proper treatment.

## Contribution

The novelty lies in documenting a rare concurrent occurrence of two distinct liver diseases and emphasizing the need for timely diagnosis.

## Key findings

- A patient was found to have both primary biliary cholangitis and sarcoidosis.
- Timely diagnosis of primary biliary cholangitis can improve liver outcomes.
- Granulomas in liver biopsy can be misleading in diagnosing the underlying condition.

## Abstract

Primary biliary cholangitis and sarcoidosis are the two most common causes of granulomatous liver disease in the US; however, their expected clinical course and management are starkly different. This case involves a patient with granulomas noted on liver biopsy, presumed secondary to known sarcoidosis, later found to have concurrent primary biliary cholangitis. Prompt diagnosis of primary biliary cholangitis is crucial as its natural course of progressive liver fibrosis can be significantly improved with treatment.

## Linked entities

- **Diseases:** primary biliary cholangitis (MONDO:0005388), sarcoidosis (MONDO:0008399)

## Full-text entities

- **Diseases:** liver fibrosis (MESH:D008103), granulomatous liver disease (MESH:D008107), Primary Biliary Cholangitis (MESH:D008105), Sarcoidosis (MESH:D012507), granulomas (MESH:D006099)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC11972662/full.md

## References

16 references — full list in the complete paper: https://tomesphere.com/paper/PMC11972662/full.md

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Source: https://tomesphere.com/paper/PMC11972662