# First person – Meri Uusi-Mäkelä and Sanna-Kaisa Emilia Harjula

PMC · DOI: 10.1242/dmm.052321 · Disease Models & Mechanisms · 2025-03-24

## TL;DR

This paper discusses the role of the inflammasome adaptor pycard in fighting Mycobacterium marinum infection in zebrafish.

## Contribution

The study identifies pycard as essential for immunity against Mycobacterium marinum in adult zebrafish.

## Key findings

- Pycard is essential for immunity against Mycobacterium marinum in zebrafish.
- The research was conducted using zebrafish as a model organism.
- The findings contribute to understanding bacterial infection models.

## Abstract

First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping researchers promote themselves alongside their papers. Meri Uusi-Mäkelä and Sanna-Kaisa Emilia Harjula are joint first authors on ‘
The inflammasome adaptor pycard is essential for immunity against Mycobacterium marinum infection in adult zebrafish’, published in DMM. Meri conducted the research described in this article while a PhD student in Mika Rämet's lab at Tampere University, Tampere, Finland. They are now a postdoc in the lab of Birgitta Henriques-Normark at Karolinska Institutet, Stockholm, Sweden, investigating bacterial infection models. Sanna-Kaisa is a postdoc in Mika Rämet's lab at Tampere University, investigating bacterial infection models in zebrafish.

## Linked entities

- **Genes:** PYCARD (PYD and CARD domain containing) [NCBI Gene 29108]
- **Diseases:** Mycobacterium marinum infection (MONDO:0043314)
- **Species:** Danio rerio (taxon 7955)

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC11972078/full.md

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11972078/full.md

## References

1 references — full list in the complete paper: https://tomesphere.com/paper/PMC11972078/full.md

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Source: https://tomesphere.com/paper/PMC11972078