# Duodenal Amyloidosis Inducing Malabsorption in Hepatitis B-Related Liver Cirrhosis: A Rare Case Presentation

## TL;DR

A rare case shows how liver cirrhosis from hepatitis B can lead to duodenal amyloidosis, causing severe malabsorption and diarrhea.

## Contribution

This case highlights the rare connection between chronic liver disease, secondary amyloidosis, and gastrointestinal malabsorption.

## Key findings

- Amyloid deposition in the duodenum was confirmed as the cause of malabsorption in a patient with HBV-related cirrhosis.
- The patient's symptoms were unresponsive to standard treatments, requiring nutritional support and symptomatic management.
- Early diagnosis and intervention are critical for managing such complex cases and preventing complications.

## Abstract

Chronic hepatitis B virus (HBV) infection is a major cause of liver cirrhosis worldwide. While hepatic complications are well-documented, extra-hepatic manifestations such as secondary amyloidosis are less common and can lead to diverse and complex clinical outcomes. Here, we present the case of a 60-year-old male with a history of chronic hepatitis B who progressed to liver cirrhosis and presented with chronic, unexplained, intractable diarrhea unresponsive to standard treatments. He also experienced significant unintentional weight loss and generalized weakness. Further investigations revealed amyloid deposition in the duodenum, confirming secondary amyloidosis affecting the gastrointestinal tract as the cause of malabsorption. Persistent diarrhea and malabsorption necessitated nutritional support and symptomatic management. This case highlights the rare association between chronic liver disease (CLD), secondary amyloidosis, and malabsorption syndrome, emphasizing the importance of clinical suspicion for timely diagnosis. Early recognition and prompt intervention are crucial to managing these complex cases, improving outcomes, and preventing further complications.