# Neopterin extends C. elegans lifespan in an ATFS-1-dependent manner

## TL;DR

Neopterin, a compound linked to immune activity and aging, extends the lifespan of C. elegans worms through a specific genetic pathway.

## Contribution

The study reveals that neopterin extends C. elegans lifespan in an ATFS-1-dependent manner.

## Key findings

- Neopterin supplementation increases the lifespan of Caenorhabditis elegans.
- Neopterin activates the mitochondrial unfolded protein response (UPRmt).
- Lifespan extension by neopterin depends on the ATFS-1 transcription factor.

## Abstract

Neopterin, a byproduct of tetrahydrobiopterin synthesis, is commonly used as a biomarker for immune system activation. In addition to its role in immune responses, neopterin levels are known to increase with age. Its impact on longevity, however, remains unclear. Here, we demonstrate that neopterin supplementation extends lifespan in

Caenorhabditis elegans
.

Additionally, neopterin shows moderate activation of the mitochondrial unfolded protein response (UPR
mt
), and that the neopterin-mediated lifespan extension is dependent on
ATFS-1
, the primary transcription factor regulating UPR
mt
. These findings highlight the need for further investigation into the biological functions and health-promoting effects of neopterin.