# Alleviation of nephropathy during aging as complications of diabetic by natural products

## TL;DR

This study shows that natural products like anserine and vitamin E can help reduce kidney damage in diabetic rats, suggesting they may be useful in managing diabetes-related complications.

## Contribution

The study introduces the combination of anserine and α-tocopherol as a potential natural treatment for diabetic nephropathy.

## Key findings

- Treatment with anserine or α-tocopherol improved glucose, HA1c, and oxidative stress markers in diabetic rats.
- The combination of anserine and α-tocopherol reduced inflammatory mediators and AGEs in diabetic rats.
- Natural supplements like anserine and α-tocopherol may protect against diabetic complications such as nephropathy.

## Abstract

The most complications of chronic diseases as diabetic during aging is micro and microvascular disorders. Consumption of functional foods is very important in protection from these complications. We studied the impact of dipeptide anserine in combination with vitamin E in prevention diabetic nephropathy in diabetic rats.

The study included 60 male albino rats sorted into five groups: GP (I): control and the other rat groups were induced diabetic by a single dose of streptozocine i.p, at dose of (55 mg/kg/b.w).GP II was considered as diabetic untreated. The other diabetic groups were treated with anserine (1mg/kg b.w, i.p), α-tocopherol (50, 00 IU/kg b.w) or combined. After 12 weeks, fasting serum was subjected for assay of glucose, glycated hemoglobin (HA1c), advanced glycated end products (AGEs), oxidative stress markers (MDA, SOD) and inflammatory markers (TNF-α and IL-6).

Data obtained revealed that, diabetic rats treated with anserine or α-tocopherol or combination improve abnormalities, glucose, HA1c, antioxidant enzymes, inflammatory mediators and AGEs versus untreated diabetic.

Dietary supplement of natural products as anserine and α-tocopherol protect against micro and microvascular system, which is suggestive as alternative or complementary therapeutic agents for diabetic complications as neuropathy, nephropathy, and CVD.