# Psychotic Onset During the Second Trimester of Pregnancy: A Case Report and Review of the Literature

**Authors:** George Mpourazanis, Ioannis Adamopoulos, Panagiotis Tsirkas, Ioannis Korkontzelos, Metodi Petkovski, Christos Akrivis, Minas Paschopoulos, Petros Petrikis

PMC · DOI: 10.7759/cureus.80065 · Cureus · 2025-03-04

## TL;DR

A pregnant woman developed psychosis during her second trimester, highlighting the risks of bipolar disorder during pregnancy.

## Contribution

This case report adds to the understanding of bipolar disorder onset during pregnancy and its management.

## Key findings

- A 29-year-old woman with bipolar disorder experienced a psychotic episode during her second trimester.
- Pharmacological treatment and close monitoring led to symptom remission postpartum.
- The case underscores the vulnerability of women with bipolar disorder during pregnancy.

## Abstract

The manuscript presents a case of a 29-year-old pregnant woman who developed a severe psychotic episode during the second trimester of her pregnancy. Bipolar disorder (BD) is a serious mood disorder of uncertain etiology marked by significant and long-lasting fluctuations in mood. It is a major cause of disability worldwide, with a higher rate of progression and frequency in women. Pregnancy represents a vulnerable period for women with BD, as hormonal and psychological changes can trigger severe mood episodes. Pharmacological treatment was given, and her pregnancy was closely monitored. A cesarean section was performed at 36 weeks, and postpartum medication adjustments were made. At six months follow-up, the patient showed signs of symptom remission, though she required subsequent psychiatric care.

## Linked entities

- **Diseases:** bipolar disorder (MONDO:0004985), psychosis (MONDO:0005485)

## Full-text entities

- **Diseases:** BD (MESH:D001714), psychiatric (MESH:D001523), psychotic episode (MESH:C580065), mood disorder (MESH:D019964)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

17 references — full list in the complete paper: https://tomesphere.com/paper/PMC11969054/full.md

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Source: https://tomesphere.com/paper/PMC11969054