# Relationship between patent ductus arteriosus and platelet indices in newborn: a systematic review and meta-analysis

## TL;DR

This study finds that newborns with patent ductus arteriosus have specific changes in platelet indices that could help in early diagnosis and treatment.

## Contribution

The study identifies novel associations between patent ductus arteriosus and specific platelet indices in newborns.

## Key findings

- Neonates with PDA have lower platelet count and plateletcrit.
- PDA neonates show higher platelet large cell ratio.
- Platelet mass, PDW, and MPV are not significantly different in PDA cases.

## Abstract

The role of platelet indices in the early hours of life and their potential association with patent ductus arteriosus (PDA) have been subjects of investigation in recent studies. This study aimed to investigate the relationship between PAD and platelet indices in newborn.

A systematic review and meta-analysis and were preformed based on Chinese databases CNKI and Wanfang database, as well as the international databases PubMed, Web of Science, Cochrane Library, and Embase from their inception to January 31, 2024.

This study included 32 literatures, with 20 of English and 12 of Chinese ones. The meta regression analysis showed that neonates with PDA tend to exhibit lower platelet count (PLT) and plateletcrit (PCT), as well as higher platelet large cell ratio (P-LCR) (all P < 0.05), while platelet mass, platelet distribution width (PDW), and mean platelet volume (MPV) remain comparable (all P > 0.05).

PDA neonates might have decreased PLT and PCT, while increased P-LCR. These dynamic shifts in platelet indices provide fresh insights into the pathophysiology of PDA and have potential to serve as important indicators for early identification, disease assessment, and personalized treatment decisions in clinical practice.