# Intrinsic neuronal resilience as a tool for therapeutic discovery

**Authors:** Stefania Corti, Eva Hedlund

PMC · DOI: 10.1093/brain/awaf010 · Brain · 2025-01-15

## TL;DR

The paper suggests that studying how neurons resist or succumb to diseases like ALS can lead to new treatments.

## Contribution

The novelty lies in proposing neuronal resilience as a framework for discovering new therapeutic targets in neurodegenerative diseases.

## Key findings

- Neuronal resilience mechanisms may offer insights into preventing or treating neurodegenerative diseases.
- Understanding resilience could lead to the identification of new molecular targets for therapy.

## Abstract

Corti and Hedlund argue that understanding the molecular underpinnings of neuronal resilience and vulnerability to neurodegenerative diseases such as ALS is key to identifying new therapeutic targets.

## Linked entities

- **Diseases:** ALS (MONDO:0004976)

## Full-text entities

- **Genes:** Mmp9 (matrix metallopeptidase 9) [NCBI Gene 17395] {aka B/MMP9, Clg4b, Gel B, MMP-9, pro-MMP-9}, TP53 (tumor protein p53) [NCBI Gene 7157] {aka BCC7, BMFS5, LFS1, P53, TRP53}, TARDBP (TAR DNA binding protein) [NCBI Gene 23435] {aka ALS10, TDP-43}, Akt1 (Akt serine/threonine kinase 1) [NCBI Gene 11651] {aka Akt, LTR-akt, PKB, PKB/Akt, PKBalpha, Rac}, GDA (guanine deaminase) [NCBI Gene 9615] {aka CYPIN, GAH, GUANASE, NEDASIN}, Nlgn1 (neuroligin 1) [NCBI Gene 192167] {aka 6330415N05Rik, NL1, Nlg1, mKIAA1070}, FUS (FUS RNA binding protein) [NCBI Gene 2521] {aka ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS}, Igf2 (insulin-like growth factor 2) [NCBI Gene 16002] {aka Igf-2, Igf-II, M6pr, Mpr, Peg2}, SYT13 (synaptotagmin 13) [NCBI Gene 57586], Igf1 (insulin-like growth factor 1) [NCBI Gene 16000] {aka C730016P09Rik, Igf-1, Igf-I}, Icam5 (intercellular adhesion molecule 5, telencephalin) [NCBI Gene 15898] {aka CD50, ICAM-3, ICAM-5, Icam3, TLN, Tlcn}, Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1) [NCBI Gene 18708] {aka PI3K, p50alpha, p55alpha, p85alpha}, Kcnq5 (potassium voltage-gated channel, subfamily Q, member 5) [NCBI Gene 226922] {aka 7730402H11, 9230107O05Rik, D1Mgi1}, CTNNB1 (catenin beta 1) [NCBI Gene 1499] {aka CTNNB, EVR7, MRD19, NEDSDV, armadillo}, Sv2a (synaptic vesicle glycoprotein 2a) [NCBI Gene 64051] {aka mKIAA0736}, C9orf72 (C9orf72-SMCR8 complex subunit) [NCBI Gene 203228] {aka ALSFTD, DENND9, DENNL72, FTDALS, FTDALS1}, Syt13 (synaptotagmin XIII) [NCBI Gene 80976] {aka 5730409J20Rik, mKIAA1427}, SOD1 (superoxide dismutase 1) [NCBI Gene 6647] {aka ALS, ALS1, HEL-S-44, IPOA, SOD, STAHP}, AKT1 (AKT serine/threonine kinase 1) [NCBI Gene 207] {aka AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA}
- **Diseases:** Neuromuscular and Rare Diseases (MESH:D035583), muscle atrophy (MESH:D009133), inflammation (MESH:D007249), Neurodegenerative diseases (MESH:D019636), SMA (MESH:D009134), motor neuron disease (MESH:D016472), ALS (MESH:D000690), degeneration (MESH:D009410)
- **Chemicals:** chloride (MESH:D002712), glucose (MESH:D005947), glutamate (MESH:D018698), calcium (MESH:D002118), kainic acid (MESH:D007608), ATP (MESH:D000255), GABA (MESH:D005680)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Adeno-associated virus (species) [taxon 272636], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11967791/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC11967791/full.md

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Source: https://tomesphere.com/paper/PMC11967791