# Successful mitral valve reconstruction using autologous pericardium in a pregnant patient with severe infective endocarditis: a case report

**Authors:** Kimiaki Anai, Kazuki Mori, Takashi Shuto, Shinji Miyamoto

PMC · DOI: 10.1186/s44215-025-00205-6 · General Thoracic and Cardiovascular Surgery Cases · 2025-04-03

## TL;DR

A pregnant woman with severe heart valve infection and failure was successfully treated with emergency surgery and valve reconstruction using her own pericardium.

## Contribution

Demonstrates successful mitral valve reconstruction using autologous pericardium in a pregnant patient with severe infective endocarditis.

## Key findings

- Emergency cesarean section improved maternal hemodynamics and allowed for subsequent valve surgery.
- Postoperative echocardiogram showed no residual mitral regurgitation after reconstruction.
- The infant survived despite premature birth and required surgery for patent ductus arteriosus.

## Abstract

A 34-year-old woman at 25 gestational weeks presented with severe respiratory distress secondary to heart failure caused by severe mitral regurgitation and infective endocarditis.

Transthoracic echocardiography revealed a large (17 mm) vegetation attached to the posteromedial commissure of the mitral valve leaflet. Owing to pulmonary edema and circulatory failure, she underwent emergency cesarean section to improve maternal hemodynamics. Postoperatively, her pulmonary edema resolved, and the hemodynamic status was stable. Thus, mitral valve surgery was scheduled 2 days later. Intraoperative findings confirmed that the posteromedial site of the mitral valve was severely damaged by vegetation and chordae tendineae rupture. The damaged mitral valve leaflet was resected, with seamless reconstruction using a glutaraldehyde-fixed autologous pericardium. Postoperative echocardiogram revealed no residual mitral regurgitation. Despite premature birth, the infant survived but required surgery for patent ductus arteriosus.

This case highlights that through timely intervention and advanced surgical techniques, a patient with severe infective endocarditis, despite being pregnant, can be successfully managed.

## Linked entities

- **Chemicals:** glutaraldehyde (PubChem CID 3485)
- **Diseases:** infective endocarditis (MONDO:0000565), pulmonary edema (MONDO:0006932), heart failure (MONDO:0005252)

## Full-text entities

- **Diseases:** respiratory distress (MESH:D012128), infective endocarditis (MESH:D004696), circulatory failure (MESH:D012769), mitral regurgitation (MESH:D008944), pulmonary edema (MESH:D011654), patent ductus arteriosus (MESH:D004374), heart failure (MESH:D006333)
- **Chemicals:** glutaraldehyde (MESH:D005976)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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Source: https://tomesphere.com/paper/PMC11967055