# Discovery of therapeutic targets in cardiovascular diseases using high-throughput chromosome conformation capture (Hi-C)

## TL;DR

This paper reviews how Hi-C technology helps identify new treatment targets for heart diseases by studying 3D chromatin structures.

## Contribution

The paper provides a comprehensive review of Hi-C-derived therapeutic targets in cardiovascular diseases.

## Key findings

- Hi-C reveals chromatin structure changes linked to cardiovascular diseases.
- Key targets identified by Hi-C may guide epigenetic therapy strategies.
- Spatial chromatin alterations influence gene expression and disease progression.

## Abstract

Epigenetic changes have been associated with several cardiovascular diseases. In recent years, epigenetic inheritance based on spatial changes has gradually attracted attention. Alterations in three-dimensional chromatin structures have been shown to regulate gene expression and influence disease onset and progression. High-throughput Chromosome Conformation Capture (Hi-C) is a powerful method to detect spatial chromatin conformation changes. Since its development, Hi-C technology has been widely adopted for discovering novel therapeutic targets in cardiovascular research. In this review, we summarize key targets identified by Hi-C in cardiovascular diseases and discuss their potential implications for epigenetic therapy.