# Rapid Differentiation of False Positives of Galactomannan Related to Contaminated Intravenous Fluids via a Pharmacokinetics Model and Innovative Web-Based Tool

**Authors:** Raeseok Lee, Suein Choi, Hwajun Cha, Dukhee Nho, Sung-Yeon Cho, Seunghoon Han, Dong-Gun Lee

PMC · DOI: 10.1093/ofid/ofaf088 · Open Forum Infectious Diseases · 2025-04-03

## TL;DR

A new tool helps doctors quickly tell the difference between real fungal infections and false test results from contaminated IV fluids.

## Contribution

A pharmacokinetic model and web-based tool were developed to rapidly identify false positives in galactomannan testing.

## Key findings

- False positives were identified within 24 hours using galactomannan kinetics.
- The tool improves diagnostic accuracy and supports early clinical decisions.
- It reduces unnecessary interventions for patients.

## Abstract

This study developed a pharmacokinetic model and web-based tool to distinguish true invasive aspergillosis from false positives caused by contaminated fluids. By analyzing galactomannan kinetics, false positives were identified within 24 hours, improving diagnostic accuracy and aiding clinicians in early decision making while minimizing unnecessary interventions.

## Linked entities

- **Diseases:** invasive aspergillosis (MONDO:0000240)

## Full-text entities

- **Diseases:** invasive aspergillosis (MESH:D055744)
- **Chemicals:** Galactomannan (MESH:C012990)

## Full text

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## Figures

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## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC11965789/full.md

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Source: https://tomesphere.com/paper/PMC11965789