# Correlation analysis on epidermal growth factor receptor (EGFR) mutations and clinicopathological characteristics in lung adenocarcinomas

## TL;DR

This study explores how EGFR mutations in lung adenocarcinomas relate to various tumor features like smoking history and tumor subtype.

## Contribution

The study identifies specific clinicopathological features correlated with EGFR mutations in lung adenocarcinomas.

## Key findings

- EGFR mutations were found in 96 out of 139 lung adenocarcinoma cases.
- Mutations were significantly associated with smoking history, tumor size, tumor subtype, rhabdomyoid differentiation, and extracellular mucus.
- These features may help predict EGFR mutation status in lung adenocarcinomas.

## Abstract

To analysis the correlation between EGFR mutations and clinicopathological features in lung adenocarcinomas.

139 lung adenocarcinoma cases from the Second Hospital of Shandong University were conducted molecular detection of EGFR mutations. Multiple clinicopathological characteristics were collected and analyzed to identify the relationship with EGFR mutations. The amplification refractory mutation system (ARMS) was performed to detect the EGFR mutations.

During the 139 cases, 96 lung adenocarcinoma cases had EGFR mutations. EGFR mutations were associated with smoking history (P=0.0311), tumor size (P=0.0247), tumor subtype (P=0.0003), rhabdomyoid differentiation (P=0.0237) and extracellular mucus (P=0.0013).

Smoking history, tumor size, tumor subtype, rhabdomyoid differentiation and extracellular mucus were related to EGFR mutations in lung adenocarcinoma. These histological characteristics might be meaningful to predict EGFR mutations.