# Calorie Restriction Extends Life Span— But Which Calories?

**Authors:** Leonie K Heilbronn, Eric Ravussin

PMC · DOI: 10.1371/journal.pmed.0020231 · PLoS Medicine · 2005-08-30

## TL;DR

A study on fruit flies shows that calorie restriction can extend lifespan, but the specific types of calories matter.

## Contribution

The study explores how different calorie sources affect lifespan in fruit flies, offering insights into human health.

## Key findings

- Calorie restriction in fruit flies increases their lifespan.
- The type of calories consumed influences the extent of lifespan extension.
- Results suggest implications for human dietary strategies related to longevity.

## Abstract

Heilbronn and Ravussin discuss the findings and implications of a study in PLoS Biology of caloric restriction in fruit flies. Are there implications for humans?

## Full-text entities

- **Genes:** SIRT1 (sirtuin 1) [NCBI Gene 23411] {aka SIR2, SIR2L1, SIR2alpha}, MTOR (mechanistic target of rapamycin kinase) [NCBI Gene 2475] {aka FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS}, InR (Insulin-like receptor) [NCBI Gene 42549] {aka 18402, CG18402, DIHR, DILR, DIR, DIRH}, Sirt1 (Sirtuin 1) [NCBI Gene 34708] {aka BEST:LD38188, CG5216, D.mel1, DSir2, Dmel\CG5216, SIR-2}
- **Diseases:** CR (MESH:D002313), obese (MESH:D009765), epilepsy (MESH:D004827), seizures (MESH:D012640), neurotoxic (MESH:D020258), Alzheimer and Parkinson diseases (MESH:D010300)
- **Chemicals:** sugar (MESH:D000073893), free radical (MESH:D005609), lipid (MESH:D008055), carbohydrate (MESH:D002241), B-hydroxybutyrate (-),  (MESH:D004041),  (MESH:D004040)
- **Species:** C. elegans [taxon 328850], Caenorhabditis elegans (species) [taxon 6239], Homo sapiens (human, species) [taxon 9606], Saccharomyces cerevisiae (baker's yeast, species) [taxon 4932], Cercopithecidae (monkey, family) [taxon 9527], Drosophila melanogaster (fruit fly, species) [taxon 7227], Rattus norvegicus (brown rat, species) [taxon 10116], Diptera (flies, order) [taxon 7147]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC1196473/full.md

## References

17 references — full list in the complete paper: https://tomesphere.com/paper/PMC1196473/full.md

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Source: https://tomesphere.com/paper/PMC1196473