# A 69-Year-Old Female with Tiredness and a Persistent Tan **Authors:** Petros Perros PMC · DOI: 10.1371/journal.pmed.0020229 · PLoS Medicine · 2005-08-30 ## TL;DR A 69-year-old woman with symptoms like tiredness, palpitations, and a persistent tan is examined to determine the underlying cause. ## Contribution The paper presents a case-based learning approach to diagnosing rare or complex medical conditions. ## Key findings - The patient's persistent tan and symptoms suggest an underlying endocrine or metabolic disorder. - Further diagnostic work-up is needed to identify the root cause of her symptoms. ## Abstract In this case-based learning article, Perros discusses the work- up a woman who presented with palpitations, tiredness, shortness of breath, and a persistent tan. ## Full-text entities - **Genes:** POMC (proopiomelanocortin) [NCBI Gene 5443] {aka ACTH, CLIP, LPH, MSH, NPP, OBAIRH}, REN (renin) [NCBI Gene 5972] {aka ADTKD4, HNFJ2, RTD}, PTHLH (parathyroid hormone like hormone) [NCBI Gene 5744] {aka BDE2, HHM, PLP, PTHR, PTHRP} - **Diseases:** toxicity (MESH:D064420), hepatocellular carcinoma (MESH:D006528), Lung, breast, gastrointestinal, and other malignancies (MESH:D001943), endocrinopathies (MESH:C567425), drop of BP (MESH:D006973), SIADH (MESH:D007177), atrial fibrillation (MESH:D001281), renal (MESH:D006030), diabetes (MESH:D003920), Weight loss (MESH:D015431), Haemochromatosis (MESH:D006432), breathlessness (MESH:D004417), critically ill (MESH:D016638), gastrointestinal symptoms (MESH:D012817), electrolyte abnormality (MESH:D014883), mixed connective tissue disorder (MESH:D008947), lung cancer (MESH:D008175), thyroid disease (MESH:D013959), infarction (MESH:D007238), adrenal disease (MESH:D000307), primary renal tubular diseases (MESH:D007674), vomiting (MESH:D014839), palpitations (MESH:D006331), antiphospholid syndrome (MESH:D013577), coma (MESH:D003128), volume depletion (MESH:C536350), Raynaud (MESH:D011928), type 1 diabetes (MESH:D003922), dehydration (MESH:D003681), Hypothyroidism (MESH:D007037), malignancies (MESH:D009369), Laboratory Abnormalities (MESH:D007757), meningococcal septicaemia (MESH:D008589), Hypotensive (MESH:D007022), neurological problems (MESH:D009461), Autoimmune hypoadrenalism (MESH:D000309), infectious diseases (MESH:D003141), Haemorrhage into the adrenals or (MESH:D006470), fits (MESH:D012640), Thyrotoxicosis (MESH:C566386), Anorexia (MESH:D000855), reduced appetite (MESH:D001068), Autoimmune adrenalitis (MESH:D001327), deterioration in level of consciousness (MESH:D003244), Pigmentation (MESH:D010859), fainting (MESH:D013575), Nausea (MESH:D009325), Generalised pigmentation (MESH:D003873), autoimmune thyroiditis (MESH:D013967), Postural dizziness (MESH:D004244), arthropathy (MESH:D007592), liver failure (MESH:D017093), lethargy (MESH:D053609), diarrhoea (MESH:D003967), fungal infection (MESH:D009181), cardiac failure (MESH:D006333), Primary Adrenal Failure (MESH:D051437), Abdominal pain (MESH:D015746), hypothalamic/pituitary disease (MESH:D007029), Addison Disease (MESH:D000224) - **Chemicals:** nifedipine (MESH:D009543), potassium (MESH:D011188), salt (MESH:D012492), dextrose (MESH:D005947), warfarin (MESH:D014859), Cortisol (MESH:D006854), urea (MESH:D014508), water (MESH:D014867), Steroid Regimen (-), steroid (MESH:D013256), thyroid-stimulating hormone (MESH:D013972), creatinine (MESH:D003404), calcium (MESH:D002118), aldosterone (MESH:D000450), Thyroxine (MESH:D013974), sodium (MESH:D012964), thiazides (MESH:D049971), digoxin (MESH:D004077) - **Species:** Homo sapiens (human, species) [taxon 9606] ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC1196471/full.md ## Figures 2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC1196471/full.md ## References 8 references — full list in the complete paper: https://tomesphere.com/paper/PMC1196471/full.md --- Source: https://tomesphere.com/paper/PMC1196471