# RETRACTION: PCAT‐1′ s Role in Wound Healing Impairment: Mitochondrial Dysfunction and Bone Marrow Stem Cell Differentiation Inhibition via PKM2/β‐Catenin Pathway and its Impact on Implant Osseo‐Integration

PMC · DOI: 10.1111/iwj.70484 · International Wound Journal · 2025-04-02

## TL;DR

This retracted paper discusses how PCAT-1 affects wound healing and implant integration through mitochondrial issues and stem cell inhibition.

## Contribution

The paper claims to identify PCAT-1's role in impairing wound healing via mitochondrial dysfunction and stem cell differentiation inhibition.

## Key findings

- PCAT-1 impairs wound healing through mitochondrial dysfunction.
- PCAT-1 inhibits bone marrow stem cell differentiation via the PKM2/β-catenin pathway.
- This impairment affects implant osseo-integration.

## Abstract

RETRACTION:

DengT.
, 
LiuQ.
, 
LiY.
, 
ZhuX.
, 
LongY.
, 
LiuB.
, 
PangJ.
, and 
ZhaoL.
, “PCAT‐1′ s Role in Wound Healing Impairment: Mitochondrial Dysfunction and Bone Marrow Stem Cell Differentiation Inhibition via PKM2/β‐Catenin Pathway and its Impact on Implant Osseo‐Integration,” International Wound Journal
21, no. 4 (2024): e14589, 10.1111/iwj.14589.38135901
PMC10961899

The above article, published online on 22 December 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor in Chief, Professor Keith Harding; and John Wiley & Sons Ltd. Following an investigation by the publisher, all parties have concluded that this article was accepted solely on the basis of a compromised peer review process. The editors have therefore decided to retract the article. The authors did not respond to our notice regarding the retraction.

## Linked entities

- **Genes:** PCAT1 (prostate cancer associated transcript 1) [NCBI Gene 100750225], PKM (pyruvate kinase M1/2) [NCBI Gene 5315], ctnnb1.S (catenin beta 1 S homeolog) [NCBI Gene 380441]

## Full-text entities

- **Genes:** CTNNB1 (catenin beta 1) [NCBI Gene 1499] {aka CTNNB, EVR7, MRD19, NEDSDV, armadillo}, PCAT1 (prostate cancer associated transcript 1) [NCBI Gene 100750225] {aka PCA1, PCAT-1, PiHL}, PKM (pyruvate kinase M1/2) [NCBI Gene 5315] {aka CTHBP, HEL-S-30, OIP3, PK3, PKM2, TCB}
- **Diseases:** Mitochondrial Dysfunction (MESH:D028361), Marrow (MESH:D001855)

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC11964497/full.md

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Source: https://tomesphere.com/paper/PMC11964497