# Ploidy plasticity drives fungal resistance to azoles used in agriculture and clinics

**Authors:** Kaustuv Sanyal, Aswathy Narayanan

PMC · DOI: 10.1371/journal.pbio.3003083 · PLOS Biology · 2025-04-02

## TL;DR

This paper explores how changes in ploidy in Candida tropicalis lead to resistance against antifungal drugs used in agriculture and medicine.

## Contribution

It reveals a novel connection between ploidy plasticity and antifungal resistance in Candida tropicalis.

## Key findings

- Ploidy plasticity is linked to the emergence of resistance to azole antifungals.
- The study focuses on Candida tropicalis as a model organism for understanding resistance mechanisms.

## Abstract

The rapid growth in antimicrobial resistance is of great medical concern. A new study in PLOS Biology unveils the link between ploidy plasticity and the emergence of antifungal resistance in Candida tropicalis.

The rapid growth in antimicrobial resistance is of great medical concern. This Primer highlights a new study in PLOS Biology that unveils the link between ploidy plasticity and the emergence of antifungal resistance in Candida tropicalis.

## Linked entities

- **Chemicals:** azoles (PubChem CID 699591)
- **Species:** Candida tropicalis (taxon 5482)

## Full-text entities

- **Chemicals:** azoles (MESH:D001393)
- **Species:** Candida tropicalis (species) [taxon 5482]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC11964256/full.md

## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC11964256/full.md

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Source: https://tomesphere.com/paper/PMC11964256