# The green side of splicing: algal spliceosome shows remarkable structural conservation

**Authors:** Wojciech P Galej

PMC · DOI: 10.1038/s44318-025-00403-6 · The EMBO Journal · 2025-03-06

## TL;DR

Researchers discovered that the spliceosome in a green alga has a structure very similar to other organisms, showing surprising conservation.

## Contribution

The study presents the first Cryo-EM structure of the spliceosome from the green alga Chlamydomonas reinhardtii.

## Key findings

- The algal spliceosome structure is remarkably similar to those in other organisms.
- This finding suggests deep evolutionary conservation of the spliceosome across species.

## Abstract

Spliceosome structures have been investigated extensively in the past decade, but most of the studies have been restricted to a handful of model organisms. New research by Lu et al, looks outside this field-of-view, reporting on the structure of the spliceosome from a unicellular green alga, Chlamydomonas reinhardtii, showing its extraordinary structural conservation.

A new study solves the Cryo-EM structure of a Chlamydomonas reinhardtii spliceosome.

## Linked entities

- **Species:** Chlamydomonas reinhardtii (taxon 3055)

## Full-text entities

- **Genes:** Prp17 [NCBI Gene 5717809], Prp18 [NCBI Gene 5719078]
- **Species:** Homo sapiens (human, species) [taxon 9606], Saccharomyces cerevisiae (baker's yeast, species) [taxon 4932], Chlamydomonas reinhardtii (species) [taxon 3055], Schizosaccharomyces pombe (fission yeast, species) [taxon 4896], PX clade (clade) [taxon 569578], Caenorhabditis elegans (species) [taxon 6239]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC11961591/full.md

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11961591/full.md

---
Source: https://tomesphere.com/paper/PMC11961591