# Metastatic MiT family/TFE translocation renal cell carcinoma in adults: case series reports and literature reviews

## TL;DR

This paper reports three adult cases of a rare kidney cancer that spreads quickly, focusing on their clinical features and treatment.

## Contribution

The study adds to the limited knowledge of MiT/TFE translocation renal cell carcinoma through case series and literature review.

## Key findings

- Two out of three patients developed liver metastases shortly after diagnosis.
- Combination therapy with targeted and immunotherapy was used in all cases.
- The study highlights the aggressive nature and young age of onset in some patients.

## Abstract

This article presents a case study of three patients diagnosed with MiT/TFE tRCC at our hospital. The tumors were located in the left kidney of all three patients, with two of them being under 30 years old. Within a short timeframe, two of all patients developed liver metastases. Genetic testing was conducted in one case, FISH testing in another, and all cases underwent a combination of targeted therapy and immunotherapy. By analyzing the clinical, pathological, and genomic characteristics of these patients, this article aims to enhance the understanding of MiT family translocation renal cell carcinoma, as well as improve the diagnosis, treatment, and prognosis of this rare form of renal cell carcinoma. Further evidence is provided to support these findings.