# Fatigue in multiple sclerosis: still elusive after all these years

**Authors:** Lauren B Krupp, Kimberly A O’Neill

PMC · DOI: 10.1093/braincomms/fcaf105 · Brain Communications · 2025-03-08

## TL;DR

The paper discusses the ongoing challenge of understanding fatigue in multiple sclerosis, referencing a study by Meijboom et al.

## Contribution

The commentary highlights the persistent difficulty in elucidating the mechanisms behind fatigue in multiple sclerosis.

## Key findings

- Fatigue remains a poorly understood symptom in multiple sclerosis.
- MRI metrics are being explored to better understand neuroinflammation and neurodegeneration in early MS.

## Abstract

This scientific commentary refers to ‘Fatigue in early multiple sclerosis: MRI metrics of neuroinflammation, relapse and neurodegeneration’, by Meijboom et al. (https://doi.org/10.1093/braincomms/fcae278).

## Linked entities

- **Diseases:** multiple sclerosis (MONDO:0005301)

## Full-text entities

- **Diseases:** neurodegeneration (MESH:D019636), Fatigue (MESH:D005221), multiple sclerosis (MESH:D009103), neuroinflammation (MESH:D000090862)

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC11961358/full.md

## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC11961358/full.md

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Source: https://tomesphere.com/paper/PMC11961358