Efficacy of Preoperative Exercise in Prehabilitation for Preventing Postoperative Sleep Disturbances and Pain: An Experimental Rat Model Study

TL;DR

This study shows that preoperative exercise in rats can reduce postoperative sleep problems and pain, suggesting prehabilitation could improve recovery for surgery patients.

Contribution

The study introduces preoperative exercise as a novel nonpharmacological prehabilitation strategy to mitigate postoperative sleep and pain issues.

Findings

Rats with preoperative exercise had reduced wake time and increased NREM sleep compared to those without exercise.

Preoperative exercise improved pain thresholds, as shown by thermal allodynia test results.

Exercise mitigated postoperative sleep disturbances to levels comparable to sham-operated controls.

Abstract

Background

Postoperative sleep disturbances and pain are common, negatively impacting recovery and quality of life. While various preventive strategies exist, the role of preoperative exercise in mitigating these effects remains underexplored.

Objective

This study evaluates the efficacy of preoperative exercise as a prehabilitation strategy to reduce postoperative sleep disturbances and pain in a rat model.

Methods

Male Wistar rats were divided into three groups: postoperative pain (PO) without preoperative exercise (N-group), PO with preoperative exercise (P-group), and a sham-operated control (S-group). Sleep patterns, including sleep duration and quality, were analyzed using EEG over a 72-hour period, starting at 8:00 a.m. on the first day of the experiment. Additionally, pain thresholds were assessed using the von Frey and Hargreaves tests.

Results

Compared to the N-group, the P-group exhibited reduced wake time and increased non-rapid eye movement (NREM) sleep duration. Additionally, the N-group showed increased wake time and decreased NREM sleep duration compared to the S-group, whereas no significant differences were observed between the P- and S-groups. The thermal allodynia test indicated a higher pain threshold in the P-group than in the N-group, although both remained lower than the S-group.

Conclusions

Our study demonstrates the efficacy of preoperative exercise as a nonpharmacological intervention for reducing postoperative sleep disturbances and alleviating pain. These findings highlight the potential benefits of prehabilitation for patients undergoing surgery.

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