560 Assessment of Ointment Containing β-sitosterol in Healing of Burns in Children up to 5 Years

TL;DR

This study shows that β-sitosterol ointment effectively and safely promotes healing in second- and third-degree burns in young children.

Contribution

The study introduces β-sitosterol ointment as a novel, effective treatment for pediatric burn healing with antimicrobial and regenerative properties.

Findings

All second-degree burns healed spontaneously with normal skin and no scarring.

Third-degree burns showed rapid debridement and successful skin graft take.

The ointment demonstrated antimicrobial activity against resistant organisms like Pseudomonas Aeruginosa and MRSA.

Abstract

To assess the efficacy and safety of burn regenerative therapy (BRT) using ointment containing β-sitosterol in healing of second- and third-degree burns in children.

The study population included 20 consecutive burned children up to 5 years, admitted with 2nd- and/or 3rd-degree burns, up to 20% TBSA. 11 girls and 9 boys (age 2.66 ± 1.73 years). All patients were treated with β-sitosterol ointment dressing every 8 hours. Burn wound surface moist swabs were taken from all children at weekly intervals and tissue biopsy was taken from deep burns only. The following was recorded during hospital say; sepsis, wound discharge, time of eschar separation and formation of granulation tissue, healing rate, need of skin graft, drug reactions and duration of hospital stay. During follow-up (6 months) assessment included final scar quality and appearance, deformity, graft take, and organ function.

Scalds were the cause of burn in 15 victims (75%). The face was involved in 7 children (35%). The mean TBSA was 10.8 ± 4.74 % and 30% of burns were 3rd-degree (deep) burns. The mean time of eschar separation was 6.253.02 days, and of healthy granulation tissue appearance was 14.63.65 days. Superficial 2nd-degree burns healed within one week with normal skin elasticity, no scar formation and no obvious pigmentation. Deep 2nd-degree burns healed within 2-3 weeks with normal skin in 18 children. Skin grafting (with 100% take) was required in children with 3rd-degree burns only. Hospital stay was 12.10 5.13 days. No disturbance of function or deformity was encountered. The commonest organisms cultured were Pseudomonas Aeruginosa and MRSA, alone or in combination.

(1) all 2nd-degree burns heal spontaneously with normal skin (2) good debridement, rapid eschar liquefaction and early granulation tissue formation in 3rd-degree burns is achieved, with complete take of skin grafts, (3) there is a definite anti-microbial action, effective against resistant organism, and (4) ointment containing β-sitosterol is safe, easy to apply, keeping a physiological moist environment and supplying indispensable nutritional substrates and enzymes necessary for physiological wound healing.

Burn regenerative therapy (BRT) using ointment containing β-sitosterol can be used to treat second- and third-degree burns in children with significant clinical efficacy.

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