# Idiopathic chilblain: a case series from Injibara General Hospital, Ethiopia

**Authors:** Alemu Bezabih Tegegnie, Tamiru Alene, Meaza Molla Sineshaw

PMC · DOI: 10.3389/fmed.2025.1564283 · 2025-03-18

## TL;DR

A study in Ethiopia reports on 12 cases of idiopathic chilblain, showing it mainly affects young women and is underreported.

## Contribution

This is the first case series on idiopathic chilblain in Ethiopia, highlighting its underreporting and clinical presentation.

## Key findings

- 75% of patients diagnosed were women with a mean age of 23.2 years.
- Most patients improved with treatment, but one had persistent disease.
- Idiopathic chilblain is underreported in Ethiopia, requiring further research.

## Abstract

Idiopathic chilblains are inflammatory lesions on the skin that typically appear after being in a cold, wet environment. The condition manifests itself as burning, soreness, and pruritis in the extremities (fingers and toes), usually occurring 12 to 24 h following a triggering event. Conservative measures are the mainstay of treatment for idiopathic chilblain; however pharmaceutical therapy may be necessary in cases that are severe or persistent. This is the only case series in Ethiopia concerning idiopathic chilblain.

From June to August of 2024, 12 individuals in the dermatology department of Injibara General Hospital in Ethiopia were diagnosed with idiopathic chilblain. Nine (or 75%) of these patients were women. This study’s mean age at diagnosis was 23.2 years (range: 3–55 years). All cases presented with itching sensations and/or pain. Only a few patients presented with swelling and color change during cold exposure. One patient presented with ulceration involving the tip of the digits. Most patients were prescribed clobetasol propionat and oral nifedipine. Others were treated with only topical corticosteroids, and few refused any medical treatment. All patients were counseled to avoid cold and keep extremities warm. Only one patient has persistent disease and the rest have completely improved.

According to the current study, young women were the group most frequently impacted by idiopathic chilblain. Idiopathic chilblain in Ethiopia is underreported, necessitating comprehensive studies involving larger patient numbers and a focus on prevalence, diagnosis, treatment, and psychosocial impact.

## Linked entities

- **Chemicals:** clobetasol propionate (PubChem CID 32798), nifedipine (PubChem CID 4485)

## Full-text entities

- **Diseases:** soreness (MESH:D063806), pain (MESH:D010146), inflammatory lesions (MESH:D007249), swelling (MESH:D004487), ulceration (MESH:D014456), Idiopathic chilblain (MESH:D002647), Idiopathic (MESH:D002311), itching sensations (MESH:D011537)
- **Chemicals:** nifedipine (MESH:D009543), clobetasol propionat (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11958165/full.md

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Source: https://tomesphere.com/paper/PMC11958165