Factors associated with elevated gentamicin trough levels in neonates: a retrospective analysis of dosing and clinical parameters

TL;DR

This study identifies factors like dosing frequency and kidney function that affect gentamicin levels in neonates.

Contribution

The study provides new insights into dosing parameters influencing gentamicin trough levels in neonates.

Findings

Shorter dosing intervals and higher creatinine levels were linked to elevated gentamicin trough levels.

Elevated CRP levels were associated with lower gentamicin trough concentrations.

All gentamicin trough levels remained within the safe 2 µg/ml threshold.

Abstract

Investigate determinants of elevated gentamicin trough levels in neonates.

This single-center retrospective analysis used a multivariate linear regression model to explore the relationship between gentamicin trough concentrations and factors such as creatinine levels, dosage, day of life, sex, CRP levels, and dosing interval in neonates.

In 215 neonates, including 68 (31.6%) premature neonates with a postmenstrual age of ≤35 weeks, shorter dosing intervals, higher creatinine levels, and increased dosage were linked to higher gentamicin trough levels. Elevated CRP levels corresponded with lower trough levels.

This study highlights the critical role of dosing frequency, kidney function, and inflammatory status in influencing gentamicin trough levels in neonates. However, all gentamicin trough levels were within the 2 µg/ml threshold.

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