# Urinary Tract Infection Caused by Gardnerella vaginalis in a Male Patient With Renal Allograft Transplant

**Authors:** Wei-Shin Lu, Michael Kleman, Vaishnavi Aradhyula, Dinkar Kaw, Caleb T Spencer

PMC · DOI: 10.7759/cureus.79847 · Cureus · 2025-02-28

## TL;DR

A male kidney transplant patient developed a urinary tract infection caused by Gardnerella vaginalis, which was successfully treated with metronidazole.

## Contribution

This case report adds to the limited literature on Gardnerella vaginalis infections in renal transplant patients.

## Key findings

- Urine cultures confirmed Gardnerella vaginalis as the causative agent of the infection.
- The patient improved with metronidazole monotherapy after initial broad-spectrum antibiotic use.
- This case emphasizes the need to consider G. vaginalis in renal transplant patients with urinary symptoms.

## Abstract

We present a case of a male patient with a history of renal allograft transplant four years prior to admission who presented with acute kidney injury. There were initial concerns for acute transplant rejection due to elevated creatinine. Urine cultures were positive for Gardnerella vaginalis. Renal biopsy results were concerning for chronic pyelonephritis. The patient developed hypertension, fever, and hematuria during the hospital course. He was initially treated with metronidazole, vancomycin, and cefepime. Broad-spectrum antibiotics were quickly discontinued, and the patient improved with metronidazole monotherapy. Patients with a history of renal transplants are often immunocompromised and at risk of infection. The few reported cases primarily involve urinary tract infections. There are scarce reports in the literature of G. vaginalis infection in patients with renal allograft transplants, such as in the present case. This case highlights the importance of considering and treating G. vaginalis in patients with renal transplants who present with symptoms of urinary tract infection.

## Linked entities

- **Chemicals:** metronidazole (PubChem CID 4173), vancomycin (PubChem CID 14969), cefepime (PubChem CID 5479537)
- **Diseases:** acute kidney injury (MONDO:0002492), acute transplant rejection (MONDO:1010187), chronic pyelonephritis (MONDO:0001110)
- **Species:** Gardnerella vaginalis (taxon 2702)

## Full-text entities

- **Diseases:** fever (MESH:D005334), chronic pyelonephritis (MESH:D011704), Urinary Tract Infection (MESH:D014552), G. vaginalis infection (MESH:D007239), hematuria (MESH:D006417), acute kidney injury (MESH:D058186), hypertension (MESH:D006973)
- **Chemicals:** creatinine (MESH:D003404), vancomycin (MESH:D014640), metronidazole (MESH:D008795), cefepime (MESH:D000077723)
- **Species:** Homo sapiens (human, species) [taxon 9606], Gardnerella vaginalis (species) [taxon 2702]

## Full text

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## Figures

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## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC11955230/full.md

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Source: https://tomesphere.com/paper/PMC11955230