Nursing Supports for Managing Nausea and Vomiting in Patients with Cancer Having a Prognosis of Months or Weeks: A Multisite Cross-Sectional Study of Palliative Care Nurses in Japan
Masamitsu Kobayashi, Kohei Kajiwara, Kimiko Nakano, Yusuke Kanno, Miharu Morikawa, Yoshinobu Matsuda, Jun Kako
TL;DR
This study explores the nursing strategies used in Japan to manage nausea and vomiting in cancer patients with a short life expectancy.
Contribution
The study identifies commonly and rarely used nursing supports for nausea and vomiting in palliative care settings in Japan.
Findings
Common nursing supports included avoiding unpleasant odors and providing shaved ice or fresh air.
Specialized techniques like acupressure and reiki were rarely used.
Simple, noninvasive methods were frequently used regardless of patient prognosis.
Abstract
This study aimed to clarify the types of nursing support provided by palliative care unit (PCU) nurses in Japan to manage nausea and vomiting in patients with cancer who have a prognosis of months or weeks. This multisite cross-sectional study surveyed registered nurses from all 389 PCUs across Japan. Eligible participants were nurses providing direct care to patients. Data were collected via online surveys from October 2023 to March 2024. The frequency of 13 types of nursing supports for nausea and vomiting was evaluated using a five-point Likert scale, stratified by patient prognosis (months or weeks). Of the 389 PCUs invited, 162 (41.6%) consented to participate. A total of 2448 nurses were invited, of which 539 (22.3%) responded. The most frequently implemented nursing supports were “avoiding unpleasant odors,” “providing shaved ice or ice chips,” “providing fresh air,” and…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
| Sex | ||
| Female | 511 | (94.8) |
| Male | 26 | (4.8) |
| Prefer not to answer | 2 | (0.4) |
| Educational background | ||
| Nursing vocational school (including junior college) | 456 | (84.6) |
| Nursing university | 64 | (11.9) |
| Master’s program (predoctoral program) | 10 | (1.9) |
| Doctoral program (postdoctoral program) | 1 | (0.2) |
| Prognosis of months | Prognosis of weeks | |
|---|---|---|
| Nursing support | ||
| Foot reflexology | ||
| Rarely | 460 (85.3) | 462 (85.7) |
| Seldom | 46 (8.5) | 42 (7.8) |
| Sometimes | 17 (3.2) | 16 (3.0) |
| Frequently | 12 (2.2) | 16 (3.0) |
| Very frequently | 4 (0.7) | 3 (0.6) |
| Acupressure | ||
| Rarely | 479 (88.9) | 478 (88.7) |
| Seldom | 36 (6.7) | 38 (7.1) |
| Sometimes | 15 (2.8) | 15 (2.8) |
| Frequently | 7 (1.3) | 6 (1.1) |
| Very frequently | 2 (0.4) | 2 (0.4) |
| Reiki | ||
| Rarely | 511 (94.8) | 512 (95.0) |
| Seldom | 13 (2.4) | 14 (2.6) |
| Sometimes | 9 (1.7) | 7 (1.3) |
| Frequently | 4 (0.7) | 5 (0.9) |
| Very frequently | 2 (0.4) | 1 (0.2) |
| Guided relaxation exercises | ||
| Rarely | 461 (85.5) | 465 (86.3) |
| Seldom | 53 (9.8) | 48 (8.9) |
| Sometimes | 18 (3.3) | 20 (3.7) |
| Frequently | 5 (0.9) | 3 (0.6) |
| Very frequently | 2 (0.4) | 3 (0.6) |
| Aromatherapy | ||
| Rarely | 390 (72.4) | 389 (72.3) |
| Seldom | 74 (13.7) | 75 (13.9) |
| Sometimes | 64 (11.9) | 61 (11.3) |
| Frequently | 7 (1.3) | 7 (1.3) |
| Very frequently | 4 (0.7) | 6 (1.1) |
| Abdominal massage | ||
| Rarely | 275 (51.0) | 279 (51.8) |
| Seldom | 134 (24.9) | 127 (23.6) |
| Sometimes | 105 (19.5) | 106 (19.7) |
| Frequently | 19 (3.5) | 21 (3.9) |
| Very frequently | 6 (1.1) | 6 (1.1) |
| Therapeutic touch | ||
| Rarely | 476 (88.3) | 475 (88.1) |
| Seldom | 30 (5.6) | 28 (5.2) |
| Sometimes | 23 (4.3) | 21 (3.9) |
| Frequently | 7 (1.3) | 10 (1.9) |
| Very frequently | 3 (0.6) | 5 (0.9) |
| Psychosocial support | ||
| Rarely | 131 (24.3) | 138 (25.7) |
| Seldom | 115 (21.4) | 123 (22.9) |
| Sometimes | 188 (34.9) | 173 (32.2) |
| Frequently | 77 (14.3) | 76 (14.1) |
| Very frequently | 27 (5.0) | 28 (5.2) |
| Self-symptom monitoring | ||
| Rarely | 361 (67.0) | 379 (70.3) |
| Seldom | 100 (18.6) | 104 (19.3) |
| Sometimes | 53 (9.8) | 32 (5.9) |
| Frequently | 18 (3.3) | 17 (3.2) |
| Very frequently | 7 (1.3) | 7 (1.3) |
| Gargling with cold water | ||
| Rarely | 46 (8.5) | 42 (7.8) |
| Seldom | 39 (7.2) | 62 (11.5) |
| Sometimes | 230 (42.7) | 230 (42.7) |
| Frequently | 164 (30.4) | 153 (28.4) |
| Very frequently | 60 (11.1) | 52 (9.6) |
| Providing fresh air | ||
| Rarely | 20 (3.7) | 14 (2.6) |
| Seldom | 36 (6.7) | 40 (7.4) |
| Sometimes | 189 (35.1) | 192 (35.6) |
| Frequently | 202 (37.5) | 202 (37.5) |
| Very frequently | 92 (17.1) | 91 (16.9) |
| Providing shaved ice or ice chips | ||
| Rarely | 27 (5.0) | 23 (4.3) |
| Seldom | 33 (6.1) | 39 (7.2) |
| Sometimes | 150 (27.8) | 142 (26.3) |
| Frequently | 220 (40.8) | 219 (40.6) |
| Very frequently | 109 (20.2) | 116 (21.5) |
| Avoiding unpleasant odors | ||
| Rarely | 14 (2.6) | 13 (2.4) |
| Seldom | 18 (3.3) | 17 (3.2) |
| Sometimes | 135 (25.0) | 135 (25.0) |
| Frequently | 253 (46.9) | 253 (46.9) |
| Very frequently | 119 (22.1) | 121 (22.4) |
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Taxonomy
TopicsNausea and vomiting management · Palliative Care and End-of-Life Issues · Anesthesia and Pain Management
Introduction
Nausea and vomiting are prevalent symptoms among patients with advanced cancer and can arise from various factors, including medications such as chemotherapy and opioids, gastrointestinal motility abnormalities, and central nervous system or psychological factors.^1,2^ These distressing symptoms are often multifactorial,^3^ can be directly or indirectly associated with the disease, and significantly impact both the physical and mental health of patients.^4^ In patients with terminal cancer, managing nausea and vomiting can be particularly challenging, as identifying and addressing the underlying causes is often difficult or impossible. Therefore, patient care primarily focuses on symptom relief. Antiemetic medications are typically recommended as the primary intervention for nausea and vomiting in patients with cancer.^5–7^ However, integrating nonpharmacological approaches is also considered beneficial in alleviating patient discomfort.^4,8^
Nurses are integral to providing nonpharmacological care for patients with terminal cancer. However, evidence supporting nursing practices for nausea and vomiting remains insufficient, and in clinical settings, nurses may rely on personal experience. This lack of evidence-based support has led to a limited understanding of the specific care practices nurses implement and the extent of their application. Therefore, this study aimed to clarify the state of nursing support provided by palliative care nurses in Japan for managing nausea and vomiting in patients with cancer who have a prognosis of months or weeks. The findings from this study are expected to provide foundational insights into current practices in clinical settings and to contribute to improving the quality of nursing support in the future.
Materials and Methods
This study is an ancillary analysis of a large-scale survey conducted among nurses working in palliative care units (PCUs) across Japan, with prior findings addressing dyspnea and caregiving burden.^9,10^
Study design and setting
This multisite, cross-sectional study involved nurses from PCUs across Japan. In Japan, specialized palliative care services include both PCUs and palliative care teams.^11^ The survey targeted all 389 PCUs nationwide, where admission charges for PCUs had been accepted as of September 14, 2023.
Participants
The study included nurses providing direct patient care in PCUs. The exclusion criteria were as follows: (1) managers of a PCU (e.g., head nurse), (2) nurses from other wards who were temporarily assigned to PCUs for training, and (3) nurses from other hospitals who were temporarily assigned to PCUs.
All target facilities were invited to participate, and explanatory documents were sent to those that agreed to participate. Nurses from consenting facilities then completed an online questionnaire, with data collected from October 1, 2023, to March 31, 2024, via LimeSurvey Cloud provided by LimeSurvey GmbH (https://www.limesurvey.org/ja).
Measurements
The online survey assessed nursing supports related to managing nausea and vomiting in patients with cancer who had a prognosis of months or weeks. Nursing supports were identified based on findings from a scoping review on nursing support for nausea and vomiting in patients with cancer and a Delphi study.^12,13^ In addition, input from a preliminary survey of nine experienced PCU nurses helped refine the list of identified nursing supports. The final set included 13 types of nursing supports: foot reflexology, acupressure, reiki, guided relaxation exercises, aromatherapy, abdominal massage, therapeutic touch, psychosocial support, self-symptom monitoring, gargling with cold water, providing fresh air, providing shaved ice or ice chips, and avoiding unpleasant odors. These supports were rated on a five-point Likert scale (1: rarely; 2: seldom; 3: sometimes; 4: frequently; 5: very frequently), with nurses indicating the extent of support usage based on whether the patient’s prognosis was of months or weeks. Participant demographic information, including sex, age, years of nursing and PCU experience, educational background, and qualifications, was also collected.
Statistical analysis
Descriptive analyses were conducted to analyze demographic information and the frequency of nursing supports. Statistical analysis was performed using EZR, a component of the R software (Saitama Medical Center, Jichi Medical University, Saitama, Japan).^14^
Research ethics
This study was approved by the Clinical Research Ethics Review Committee of Mie University Hospital (U2023-011) and registered with the University Hospital Medical Information Network, Japan (UMIN0000 52329).
Results
All 389 PCUs in Japan were invited to participate in the study, with 162 facilities (41.6%) consenting to participate. A total of 2448 nurses from these 162 PCUs were invited to complete the questionnaire, and 539 (22.3%) responded. The average age of the respondents was 42.3 ± 9.8 years, with an average of 18.6 ± 9.6 years of nursing experience and 4.8 ± 4.3 years of experience specifically in PCU settings (Table 1).
Among patients with a prognosis of months, the most frequently (frequently/very frequently) reported nursing supports included “avoiding unpleasant odors,” followed by “providing shaved ice or ice chips,” “providing fresh air,” and “gargling with cold water,” and those that were rarely or seldom utilized were “reiki,” “acupressure,” “guided relaxation exercises,” “therapeutic touch,” and “foot reflexology.” These patterns remained consistent for patients with a prognosis of weeks as well (Table 2).
Discussion
This study investigated the nursing support provided by PCU nurses in Japan for managing nausea and vomiting in patients with cancer who had a prognosis of months or weeks. The results showed that the frequency of nursing support was nearly the same, regardless of the patient’s prognosis.
Nursing supports such as “avoiding unpleasant odors,” “providing shaved ice or ice chips,” “providing fresh air,” and “gargling with cold water” were frequently implemented in both prognosis groups. These supports are clinically favorable because they are noninvasive, low-cost, and easily accessible. In addition, patients can easily self-administer these supports at their own pace, with family assistance where needed. Among these supports, avoiding unpleasant odors is particularly effective for managing nausea and vomiting, as strong or offensive smells can activate the vomit center in the brain, primarily through the olfactory system.^15^ Therefore, maintaining a clean personal environment and avoiding any odors that may cause discomfort are crucial in managing nausea and vomiting in patients with cancer. Providing shaved ice or ice chips may alleviate nausea and vomiting by cooling the oral cavity; in patients undergoing chemotherapy, oral cryotherapy has been shown to reduce oral discomfort and associated nausea and vomiting.^16^ However, although this approach provides comfort and potentially reduces these symptoms, its benefits in patients with terminal cancer remain uncertain. Providing fresh air improves patient comfort and is a common practice in palliative care settings and for patients undergoing cancer treatment,^17^ although the mechanism by which it reduces nausea and vomiting is not understood. Gargling with cold water may relieve nausea by cooling the mouth and throat and alleviating xerostomia and bad taste, both of which can contribute to nausea and vomiting. Although drinking cold water has been shown to reduce chemotherapy-induced nausea and vomiting,^18^ it may not be feasible in terminal care settings, making assisted gargling a practical alternative.
In contrast, nursing supports such as “reiki,” “acupressure,” “guided relaxation exercises,” “therapeutic touch,” and “foot reflexology” were rarely provided in either prognosis period. The infrequent use of these supports may be attributed to the specialized knowledge and skills required for their implementation. In addition, limited evidence supports their effectiveness, highlighting the need for further research.^12^ If future studies confirm their effectiveness, it will be necessary to create an environment that facilitates their adoption.
Limitations
This study had several limitations. First, the low response rate might have limited the representativeness of the findings, thereby restricting the generalizability of our results. Second, as the participants in this study were nurses working exclusively in Japan, the findings might have been influenced by cultural factors unique to the Japanese health care setting. Therefore, the broader applicability of these results to other countries may be limited. Third, the reported frequencies of nursing supports may not accurately reflect their actual implementation in clinical settings. Despite these limitations, we believe this study provides valuable insights that can inform future research and clinical practice.
Conclusions
This study found that Japanese PCU nurses provide similar support for managing nausea and vomiting in patients with terminal cancer, regardless of prognosis. The most frequently implemented nursing supports were “avoiding unpleasant odors,” “providing shaved ice or ice chips,” “providing fresh air,” and “gargling with cold water.” Future research should evaluate the effectiveness of these frequently implemented nursing supports to optimize care for patients with terminal cancer.
The reference list from the paper itself. Each links out to its DOI / PubMed record.
- 1Teunissen SC, Wesker W, Kruitwagen C, et al. Symptom prevalence in patients with incurable cancer: A systematic review. J Pain Symptom Manage 2007;34(1):94–104; doi: 10.1016/j.jpainsymman.2006.10.01517509812 · doi ↗ · pubmed ↗
- 2Solano JP, Gomes B, Higginson IJ. A comparison of symptom prevalence in far advanced cancer, AIDS, heart disease, chronic obstructive pulmonary disease and renal disease. J Pain Symptom Manage 2006;31(1):58–69; doi: 10.1016/j.jpainsymman.2005.06.00716442483 · doi ↗ · pubmed ↗
- 3Collett D, Chow K. Nausea and Vomiting. In: Oxford Textbook of Palliative Nursing (Ferrell BR, Paice JA. eds.) Oxford University Press: New York; 2019; pp. 149–162.
- 4Farrell C, Brearley SG, Pilling M, et al. The impact of chemotherapy-related nausea on patients’ nutritional status, psychological distress and quality of life. Support Care Cancer 2013;21(1):59–66; doi: 10.1007/s 00520-012-1493-922610269 · doi ↗ · pubmed ↗
- 5Dupuis LL, Roscoe JA, Olver I, et al. 2016 updated MASCC/ESMO consensus recommendations: Anticipatory nausea and vomiting in children and adults receiving chemotherapy. Support Care Cancer 2017;25(1):317–321; doi: 10.1007/s 00520-016-3330-z 27510314 · doi ↗ · pubmed ↗
- 6Hesketh PJ, Kris MG, Basch E, et al. Antiemetics: ASCO guideline update. J Clin Oncol 2020;38(24):2782–2797; doi: 10.1200/JCO.20.0129632658626 · doi ↗ · pubmed ↗
- 7NCCN Guidelines Version 1. Antiemesis. Plymouth Meeting, PA; 2023. Available from: https://www.nccn.org/professionals/physician_gls/pdf/antiemesis.pdf [Last accessed: October 26, 2024].
- 8Japanese Society of Palliative Medicine. Clinical Guidelines for Gastrointestinal Symptoms in Cancer Patients. Kanehara: Tokyo; 2017.