# Deguelin promotes longevity and healthspan through C. elegans fmo-4

## TL;DR

Deguelin, a mitochondrial complex I inhibitor, extends lifespan and healthspan in C. elegans by acting through the FMO-4 enzyme.

## Contribution

The study identifies FMO-4 as a key dependency for deguelin's longevity-promoting effects in C. elegans.

## Key findings

- Deguelin increases lifespan in C. elegans.
- Deguelin's effects on longevity depend on FMO-4 and other FMO enzymes.
- FMO enzymes may work together to promote longevity.

## Abstract

There are multiple approaches to longevity interventions in

Caenorhabditis elegans
,

including genetic factors
that are necessary or sufficient for lifespan extension and pharmacological agents that modify physiology to extend lifespan. Many pharmacological interventions act through known genetic pathways to promote longevity. Here, we show that the mitochondrial complex I inhibitor, deguelin, promotes lifespan extension and healthspan in an
fmo-4-
dependent manner. Our results confirm that deguelin increases lifespan and indicate that deguelin induces and requires multiple FMO enzymes to extend lifespan in

C. elegans

, suggesting these enzymes may promote longevity in a coordinated fashion.