# Generalized Tremors in Dogs: 198 Cases (2003–2023)

## TL;DR

This study examines 198 dogs with generalized tremors to identify the most common causes and clinical features, helping veterinarians better diagnose and treat these conditions.

## Contribution

The study provides a large-scale retrospective analysis of generalized tremor causes in dogs, highlighting intoxication and IGTS as the most frequent.

## Key findings

- Intoxication was the most common cause (46%) of generalized tremors in dogs.
- Idiopathic generalized tremor syndrome (IGTS) was the second most common cause (24.7%).
- Clinical features like age, gender, and presentation patterns helped differentiate between intoxication and IGTS.

## Abstract

Diseases associated with generalized tremors in dogs have not been extensively investigated in a large population of dogs.

Describe semiology, tremor phenotype, and diseases associated with generalized tremors in dogs, and identify clinical features that could be associated with the underlying disease.

A total of 198 dogs.

Retrospective, single‐center study of dogs with generalized tremors and a final or presumptive diagnosis between January 2003 and December 2023.

The most common diseases associated with generalized tremors in dogs were intoxication (91/198; 46%), idiopathic generalized tremor syndrome (IGTS; 49/198; 24.7%), hypocalcemia (13/198; 6.6%), meningoencephalitis of unknown origin (MUO; 9/198; 4.5%), hypoglycemia (6/198; 3%), hypercalcemia (5/198; 2.5%) and degenerative encephalopathies (5/198; 2.5%). Dogs with IGTS were females (p = 0.002), younger (p = 0.002) with an acute progressive lateralizing presentation (p < 0.001 for all three), compared to dogs with intoxication that were males (p = 0.002), young and middle‐aged (p = 0.002) with a hyperacute nonprogressive symmetric presentation (p < 0.001 for all three). Behavioral changes (p = 0.01), hypersalivation (p = 0.04), abnormal mentation (p = 0.01), bilateral mydriasis (p = 0.02) or generalized hyperesthesia (p = 0.002) were common in intoxication, whereas hyporexia and vestibulocerebellar signs (p < 0.001 both) were common in IGTS. Dogs manifested only tremors in intoxication (45%) compared with IGTS (22%; p = 0.01). Improvement within 48 h from the onset of signs without corticosteroid treatment occurred exclusively in dogs with intoxication (p < 0.001).

Intoxication and IGTS were the most common diseases associated with generalized tremors in dogs. Historical and clinical features may aid the clinician in adjusting their differential diagnoses and formulating a diagnostic and treatment plan.