Harlequin Syndrome Caused by Multinodular Goitre
Andrew Strong, Justin Siew Yoong Tu, Sonya Kyi, Tissa Wijeratne

TL;DR
This paper discusses a rare case of Harlequin syndrome caused by a multinodular goitre, highlighting its neurological effects and differences from Horner’s syndrome.
Contribution
The novelty lies in presenting a rare case of Harlequin syndrome linked to a non-toxic multinodular goitre and providing a detailed neuroanatomical review.
Findings
Harlequin syndrome was caused by compression of the sympathetic trunk from a multinodular goitre.
The case highlights the importance of distinguishing Harlequin syndrome from Horner’s syndrome.
The paper provides insights into sympathetic facial innervation for physicians.
Abstract
Harlequin syndrome is a rare neurological disorder characterised by hemifacial flushing and sweating. We present a case of Harlequin syndrome with evidence of compression of the sympathetic trunk due to a non-toxic multinodular goitre. We review the neuroanatomy of this fascinating condition, particularly in relation to the more common and often sinister Horner’s syndrome, to convey a deeper understanding of the nuances of sympathetic facial innervation to the keen physician.
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Taxonomy
TopicsSympathectomy and Hyperhidrosis Treatments · Migraine and Headache Studies · Ophthalmology and Eye Disorders
