# Population-Based Matched Cohort Study of COVID-19 Healthcare Costs, Ontario, Canada

**Authors:** Beate Sander, Sharmistha Mishra, Sarah Swayze, Yeva Sahakyan, Raquel Duchen, Kieran Quinn, Naveed Janjua, Hind Sbihi, Jeffrey Kwong

PMC · DOI: 10.3201/eid3104.241463 · 2025-04-01

## TL;DR

This study estimates the healthcare costs of COVID-19 in Ontario, Canada, showing significant long-term financial impacts on the health system.

## Contribution

The study provides phase-specific and survival-adjusted healthcare cost estimates for COVID-19 using a large matched cohort.

## Key findings

- Mean cumulative survival-adjusted cost at 360 days was $2,553 per person.
- SARS-CoV-2 infection is associated with substantial long-term healthcare costs.
- Phase-specific costs can inform budget and pandemic planning.

## Abstract

Estimates of COVID-19–related healthcare costs are key to health system planning, but attributable cost data remain limited. We characterized healthcare costs attributable to COVID-19 through a population-based matched cohort study in Ontario, Canada, by using health administrative data. We matched SARS-CoV-2–positive persons from 2020 to unexposed historical control persons from 2016–2018. We estimated phase-based and survival-adjusted COVID-19–attributable healthcare costs from the health system perspective. We matched 159,817 persons. Mean (95% CI) attributable 10-day costs per person were $1 ($–4 to $6) preindex, $240 ($231–$249) during acute care, $18 ($14–$21) in postacute phases, $3,928 ($3,471–$4,384) in the terminal phase for early deaths, and $1,781 ($1,182–$2,380) for late deaths. Mean cumulative survival-adjusted cost at 360 days was $2,553 ($2,348–$2,756) per person. SARS-CoV-2 infection is associated with substantial long-term healthcare costs, consistent with understanding of post-COVID condition. Determining phase-specific costs can inform budget and pandemic planning.

## Linked entities

- **Diseases:** COVID-19 (MONDO:0100096)

## Full-text entities

- **Diseases:** deaths (MESH:D003643), COVID-19 (MESH:D000086382), post-COVID condition (MESH:D000094024)
- **Species:** Homo sapiens (human, species) [taxon 9606], Severe acute respiratory syndrome coronavirus 2 (no rank) [taxon 2697049]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11950279/full.md

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Source: https://tomesphere.com/paper/PMC11950279