# Editorial Expression of Concern: A novel 4-aminoquinazoline derivative, DHW-208, suppresses the growth of human breast cancer cells by targeting the PI3K/AKT/mTOR pathway

**Authors:** Shu Wang, Yingshi Zhang, Tianshu Ren, Qiong Wu, Hongyuan Lu, Xiaochun Qin, Yuyan Liu, Huaiwei Ding, Qingchun Zhao

PMC · DOI: 10.1038/s41419-025-07539-7 · Cell Death & Disease · 2025-03-27

## Full-text entities

- **Genes:** MTOR (mechanistic target of rapamycin kinase) [NCBI Gene 2475] {aka FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS}, AKT1 (AKT serine/threonine kinase 1) [NCBI Gene 207] {aka AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA}
- **Diseases:** breast cancer (MESH:D001943)
- **Chemicals:** 4-aminoquinazoline (MESH:C573775), DHW-208 (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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Source: https://tomesphere.com/paper/PMC11950225