# Severe Hyponatremia as a Complication of Sepsis: A Case Report

**Authors:** Logan A Goddard, Adrienne Clermont, Mark Supino

PMC · DOI: 10.7759/cureus.79648 · Cureus · 2025-02-25

## TL;DR

A young, healthy man developed severe low sodium levels due to sepsis from a skin infection and pneumonia, highlighting the importance of timely treatment.

## Contribution

This case report presents an uncommon instance of severe hyponatremia in a young patient without prior health issues, caused by sepsis.

## Key findings

- A 26-year-old male with no medical history developed severe hyponatremia (117 mEq/L) due to sepsis from a skin abscess and pneumonia.
- The patient required ICU admission and intubation but made a full recovery after prolonged treatment.
- The case emphasizes the critical nature of identifying and managing hyponatremia in sepsis to prevent severe outcomes.

## Abstract

Severe infections such as pneumonia can cause hyponatremia. This phenomenon is widely attributed to the syndrome of inappropriate antidiuretic hormone secretion (SIADH), although the mechanism is not fully understood. Healthcare providers must identify and treat the cause of low sodium correctly to prevent elevated morbidity and mortality. This report describes an uncommon case of severe hyponatremia in a 26-year-old male with no known medical history and no risk factors for immunosuppression. He presented with worsening body pain and shortness of breath, and he noted an ulcerated lesion on his lower back that had drained purulent fluid in the past week. Laboratory studies revealed severe hyponatremia, with a sodium level of 117 mEq/L, and chest X-ray depicted bilateral interstitial opacities concerning for pneumonia. The patient was started on normal saline, empiric antibiotics, and bilevel positive airway pressure in the emergency department. He was admitted to the intensive care unit (ICU) and subsequently required intubation. After a prolonged ICU course, the patient eventually made a full recovery with no residual deficits. Our report demonstrates an uncommon case of severe hyponatremia in a young, previously healthy patient. He presented with alarmingly low sodium levels, likely secondary to SIADH in the setting of sepsis due to skin abscess and pneumonia. The severity of the patient’s hyponatremia was a fundamental factor in identifying the critical nature of his disease and the need for expeditious treatment. Familiarity with appropriate management of hyponatremia is crucial for emergency physicians.

## Linked entities

- **Diseases:** pneumonia (MONDO:0005249)

## Full-text entities

- **Diseases:** shortness of breath (MESH:D004417), SIADH (MESH:D007177), skin abscess (MESH:D000038), Sepsis (MESH:D018805), pneumonia (MESH:D011014), interstitial opacities (MESH:D003318), pain (MESH:D010146), ulcerated lesion (MESH:D014456), infections (MESH:D007239), Hyponatremia (MESH:D007010)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11949546/full.md

## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC11949546/full.md

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Source: https://tomesphere.com/paper/PMC11949546