# Non-invasive Assessment of Intracranial Pressure in Severe Burned Patients: From Animal Models to Bedside

**Authors:** Maria Notaro, Laura M.B. Belotti, Marco D. Serafino, Adele Longobardi, Romolo Villani, Raffaele Aspide

PMC · DOI: 10.37825/2239-9747.1054 · Translational Medicine @ UniSa · 2024-07-25

## TL;DR

This study explores non-invasive methods to assess intracranial pressure in severe burn patients, using techniques like ultrasound and transcranial Doppler.

## Contribution

The study demonstrates the feasibility of non-invasive methods for diagnosing intracranial hypertension in burn patients.

## Key findings

- No pathological values were identified in 20 patients studied.
- Non-invasive methods like optic nerve sheath diameter and transcranial Doppler are applicable to burn patients.
- These methods may reduce the incidence of neuro-complications in this population.

## Abstract

Some is known from studies on burn animal models. Burn patients can develop intracranial hypertension. The aim of study is to evaluate feasibility of non-invasive methods for the diagnosis of intracranial hypertension.

Burns patients were enrolled and studied through ultrasound measurement of optic nerve sheath diameter and transcranial Doppler.

In the 20 patients studied, no pathological values were identified without correlations with the extension of the burn.

Starting from animal models, it is legitimate to suspect an underestimation of neuro-complications. The study demonstrates that these methods are applicable to this population, representing an effective method reducing the incidence of neuro-complications.

## Linked entities

- **Diseases:** intracranial hypertension (MONDO:0006810), burns (MONDO:0043519)

## Full-text entities

- **Diseases:** intracranial hypertension (MESH:D019586), Burn (MESH:D002056), neuro-complications (MESH:D008107)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

29 references — full list in the complete paper: https://tomesphere.com/paper/PMC11949496/full.md

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Source: https://tomesphere.com/paper/PMC11949496