# Conservative Management of Thrombotic Microangiopathy in a Renal Transplant Recipient: The Importance of Early Recognition

**Authors:** Ahmad S. Matarneh, Sundus Sardar, Abdel‐rauof Akkari, Pankhuri Mohan, Naman Trivedi, Gurwant Kaur, Nasrollah Ghahramani

PMC · DOI: 10.1002/ccr3.70351 · Clinical Case Reports · 2025-03-27

## TL;DR

This paper discusses the importance of early detection and conservative treatment of a rare kidney transplant complication linked to a drug.

## Contribution

The paper emphasizes the novel approach of early recognition and conservative management to prevent graft loss in TMA cases.

## Key findings

- TMA in renal transplant recipients is often linked to tacrolimus.
- Stopping tacrolimus promptly can prevent graft loss.
- Early diagnosis and vigilance for subtle signs are crucial for effective management.

## Abstract

Thrombotic microangiopathy (TMA) is a rare but severe complication in renal transplant recipients, often linked to tacrolimus. Early recognition and intervention, such as stopping the drug, are crucial to preventing graft loss. This case highlights the importance of prompt diagnosis and vigilance for subtle signs to ensure effective management.

## Linked entities

- **Chemicals:** tacrolimus (PubChem CID 445643)
- **Diseases:** thrombotic microangiopathy (MONDO:0019737)

## Full-text entities

- **Diseases:** TMA (MESH:D057049)
- **Chemicals:** tacrolimus (MESH:D016559)

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC11947423/full.md

## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC11947423/full.md

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Source: https://tomesphere.com/paper/PMC11947423