# Visible-Light-Mediated Synthesis of Anomeric S-Aryl Glycosides via Electron Donor–Acceptor Complex Using Thianthrenium Salts

## TL;DR

A new green method for making S-Aryl glycosides uses light and an electron donor-acceptor complex without metals or photocatalysts.

## Contribution

A metal- and photocatalyst-free method for synthesizing S-Aryl glycosides using visible light and EDA complexes.

## Key findings

- A mild and sustainable synthesis of S-Aryl glycosides was developed using 1-thiosugar and aryl thianthrenium salt.
- The method avoids traditional electron-rich thiols and uses visible light for the reaction.
- This approach provides a greener alternative for glycoside synthesis.

## Abstract

S-Aryl glycosides are not only popular glycosyl donors in carbohydrate chemistry but also serve as valuable tools in various biological studies, which has brought significant attention to their preparation. However, there remains a pressing need for greener synthesis methods in this area. In response, a mild, sustainable, and metal- and photocatalyst-free electron donor–acceptor (EDA)-mediated approach for synthesizing S-Aryl glycosides using 1-thiosugar and aryl thianthrenium salt was developed. Our strategy utilizes 1-thiosugar as the donor, overcoming the traditional reliance on electron-rich thiols, such as aryl or carbonyl thiols, typically required for forming EDA complexes.