# RETRACTED: El-Gowily et al. Tioconazole and Chloroquine Act Synergistically to Combat Doxorubicin-Induced Toxicity via Inactivation of PI3K/AKT/mTOR Signaling Mediated ROS-Dependent Apoptosis and Autophagic Flux Inhibition in MCF-7 Breast Cancer Cells. Pharmaceuticals 2021, 14, 254

**Authors:** Afnan H. El-Gowily, Samah A. Loutfy, Ehab M. M. Ali, Tarek M. Mohamed, Mohammed A. Mansour

PMC · DOI: 10.3390/ph18030338 · 2025-02-27

## Full-text entities

- **Genes:** MTOR (mechanistic target of rapamycin kinase) [NCBI Gene 2475] {aka FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS}, AKT1 (AKT serine/threonine kinase 1) [NCBI Gene 207] {aka AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA}
- **Diseases:** Toxicity (MESH:D064420), Breast Cancer (MESH:D001943)
- **Chemicals:** Doxorubicin (MESH:D004317), Tioconazole (MESH:C020527), ROS (-), Chloroquine (MESH:D002738)
- **Cell lines:** MCF-7 — Homo sapiens (Human), Invasive breast carcinoma of no special type, Cancer cell line (CVCL_0031)

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Source: https://tomesphere.com/paper/PMC11944725