# Misdiagnosis of Acute Limb Ischemia from Non-Vascular Specialists Results in a Delayed Presentation and Negatively Affects Patients’ Outcomes

## TL;DR

Misdiagnosis of acute limb ischemia by non-vascular doctors delays treatment and worsens patient outcomes, including limb loss and death.

## Contribution

This study shows how misdiagnosis by non-vascular specialists leads to worse outcomes for acute limb ischemia patients.

## Key findings

- 14 out of 280 ALI patients were initially misdiagnosed, leading to delayed treatment.
- Patients with delayed diagnosis had a 65% limb salvage rate versus 89% for timely diagnosis.
- Delayed diagnosis also led to a 65% reintervention rate versus 18% for timely diagnosis.

## Abstract

Background/Objectives: Acute Limb Ischemia (ALI) is a vascular emergency which is accompanied by a significant risk of limb loss or even death. Rapid restoration of arterial perfusion using surgical and/or endovascular techniques is crucial for limb salvage. Undeniably, an accurate and prompt diagnosis is the first step to improve patient prognosis. The typical clinical presentation is not always present and the variety of symptoms may result in non-vascular specialists missing the diagnosis. Methods: In this single-center retrospective descriptive study, we reviewed all patients hospitalized between January 2018 and January 2024 for ALI. Patients who were initially misdiagnosed, causing a delayed diagnosis > 24 h, and who therefore did not receive timely treatment, were identified. Moreover, patients with a timely diagnosis of ALI who were treated in our institution during the same time period were collected. Results: Among 280 ALI patients, 14 were initially misdiagnosed. The median time from initial symptoms to definite diagnosis was 38.8 days (range 1.5–365). Several specialties such as orthopedic surgeons, neurologists, and general practitioners were involved in patients’ initial assessment. Three patients underwent primary amputation due to irreversible ALI, while nine underwent revascularization and one conservative treatment. Thirty-day limb salvage rate was 9/14 and thirty-day mortality was observed in one patient. Secondary interventions were needed in 65% of these cases. Patients with a delayed ALI diagnosis, when compared to those with a timely diagnosis, presented a significantly lower limb salvage rate (65% vs. 89%, p-value = 0.02) and a significantly higher rate of reinterventions (65% vs. 18%, p-value < 0.001). Conclusions: Many patients with ALI are primarily referred to non-vascular specialties. Misdiagnosed and mistreated ALI negatively affects outcomes.