# Prognostic and Predictive Value of Systemic Inflammatory Markers in Epithelial Ovarian Cancer

## TL;DR

This study explores how inflammation-related blood markers might predict outcomes in ovarian cancer patients, but found mixed results needing further research.

## Contribution

The study evaluates systemic inflammatory markers as potential prognostic and predictive tools in epithelial ovarian cancer.

## Key findings

- Elevated NLR and PLR were linked to worse progression-free and overall survival in univariate analysis.
- Systemic inflammatory markers did not show statistical significance in multivariate analysis.
- Histopathological type, PLR, and surgical approach predicted platinum resistance.

## Abstract

Background and Objectives: Epithelial ovarian cancer (EOC) remains a significant global health challenge. While traditional prognostic factors are well established, emerging biomarkers continue to gain attention. Materials and Methods: This retrospective study evaluated the impact of systemic inflammatory markers on progression-free survival (PFS) and overall survival (OS) in 154 EOC patients. Pre-treatment neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and systemic inflammatory index (SII) were calculated and categorized into low and high groups. Univariate and multivariate analyses were conducted to identify independent prognostic factors, while logistic regression analysis was used to determine predictors of platinum resistance. Results: In the univariate analysis, elevated NLR and PLR were associated with poorer PFS and OS. However, these markers did not maintain statistical significance in the multivariate analysis. Although SII demonstrated a trend toward worse outcomes, it did not reach statistical significance. Histopathological type, PLR, and surgical approach were identified as independent predictors of platinum resistance. Conclusions: Our findings indicate that systemic inflammatory markers may hold prognostic value in EOC; however, further validation through larger prospective studies is necessary.