# GPCR Sense Communication Among Interaction Nematodes with Other Organisms

**Authors:** Jie Wang, Changying Guo, Xiaoli Wei, Xiaojian Pu, Yuanyuan Zhao, Chengti Xu, Wei Wang

PMC · DOI: 10.3390/ijms26062822 · International Journal of Molecular Sciences · 2025-03-20

## TL;DR

This paper explores how nematodes communicate with other species using GPCRs, highlighting their role in interspecies interactions and pest control.

## Contribution

The paper introduces the role of GPCRs in nematode interactions with other species and emphasizes their potential for pest control.

## Key findings

- GPCRs facilitate communication between nematodes and other species like plants, insects, and fungi.
- flp genes, functioning as GPCRs, influence nematode interactions with varying degrees of impact.
- Understanding GPCR roles can aid in developing strategies for pest control.

## Abstract

Interactions between species give rise to chemical pathways of communication that regulate the interactions of transboundary species. The communication between nematodes and other species primarily occurs through the regulation of chemicals, with key species including plants, insects, bacteria, and nematode-trapping fungi that are closely associated with nematodes. G protein-coupled receptors (GPCRs) play a crucial role in interspecies communication. Certain flp genes, which function as GPCRs, exert varying degrees of influence on how nematodes interact with other species. These receptors facilitate the transmission of corresponding signals, thereby completing the interactions between species. This paper introduces the interactions between nematodes and other species and discusses the role of GPCRs in these organisms, contributing to a deeper understanding of the impact and significance of GPCRs in cross-border regulation between nematodes and other species. Furthermore, it is essential to leverage GPCRs in efforts to control pests.

## Linked entities

- **Genes:** FLP (Duplicated homeodomain-like superfamily protein) [NCBI Gene 837997]
- **Species:** Nematodes (taxon 333870), Bacteria (taxon 2)

## Full-text entities

- **Genes:** VN1R17P (vomeronasal 1 receptor 17 pseudogene) [NCBI Gene 441931] {aka GPCR}

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11943259/full.md

## References

113 references — full list in the complete paper: https://tomesphere.com/paper/PMC11943259/full.md

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Source: https://tomesphere.com/paper/PMC11943259