# The Public Knowledge of Precision Medicine and Genomic Research: A Survey in the Aosta Valley

## TL;DR

This study explores public willingness to participate in a genomic research project in the Aosta Valley and finds high interest, influenced by factors like age and education.

## Contribution

The study provides novel insights into public attitudes toward precision medicine and genomic research in a specific regional context.

## Key findings

- 92.6% of respondents expressed willingness to participate in the genomic project.
- Age, education, and healthcare experience significantly influence awareness of precision medicine.
- Subgroups differ in reasons for participation and types of biological samples they are willing to donate.

## Abstract

Background: Precision medicine (PM) considers the genetic variability of individuals to identify tailored diagnosis and treatments. It relies on the possibility of gathering the widest possible health data and genetic information from individuals to obtain a broad pool of comparative data. To achieve this goal, the Region of Valle d’Aosta, since 2019, has co-financed the research center CMP3VdA, aiming to sequence 5000 genomes of patients with neurodevelopmental, neurodegenerative, oncological, and organ transplantation diseases, and to investigate the genetic variability of the resident population. Methods: This paper presents the results of an online survey of 472 (328F) respondents regarding willingness to participate in the genomic project and awareness, attitudes, and concerns about PM. Results: The main results show that the vast majority (92.6%) would be willing to participate—a higher percentage than in previous studies. Age, education, and prior experience in the healthcare sector are significant factors influencing the awareness of PM. Additionally, subgroups organized by age, gender, and religiosity show significant differences with respect to participants’ reasons for participating in research and which types of biological samples they would be willing to donate. Conclusions: Our findings can serve as a guide for stakeholders—particularly policymakers—to target institutional communication and achieve maximum participation in genomic research projects.