# Proteolysis of Extracellular Matrix in Human Disease 2.0

**Authors:** Hironobu Yamashita

PMC · DOI: 10.3390/ijms26062700 · International Journal of Molecular Sciences · 2025-03-17

## Full-text entities

- **Genes:** SNAI1 (snail family transcriptional repressor 1) [NCBI Gene 6615] {aka SLUGH2, SNA, SNAH, SNAIL, SNAIL1, dJ710H13.1}, MMRN1 (multimerin 1) [NCBI Gene 22915] {aka ECM, EMILIN4, GPIa*, MMRN}, TGFB1 (transforming growth factor beta 1) [NCBI Gene 7040] {aka CAEND1, CED, DPD1, IBDIMDE, LAP, TGF-beta1}, SPARC (secreted protein acidic and cysteine rich) [NCBI Gene 6678] {aka BM-40, OI17, ON, ONT}, POSTN (periostin) [NCBI Gene 10631] {aka OSF-2, OSF2, PDLPOSTN, PN}, HPSE (heparanase) [NCBI Gene 10855] {aka HPA, HPA1, HPR1, HPSE1, HSE1}, SPP1 (secreted phosphoprotein 1) [NCBI Gene 6696] {aka BNSP, BSPI, ETA-1, OPN}, Eln (elastin) [NCBI Gene 13717] {aka E030024M20Rik}, Fbn1 (fibrillin 1) [NCBI Gene 14118] {aka B430209H23, Fib-1, Tsk}, TNC (tenascin C) [NCBI Gene 3371] {aka 150-225, DFNA56, GMEM, GP, HXB, JI}, MMP14 (matrix metallopeptidase 14) [NCBI Gene 4323] {aka MMP-14, MMP-X1, MT-MMP, MT-MMP 1, MT1-MMP, MT1MMP}
- **Diseases:** Glioblastoma (MESH:D005909), Intervertebral Disc Degeneration (MESH:D055959), perlecan deficiency (MESH:D009084), cardiomyocyte hypertrophy (MESH:D006984), back pain (MESH:D001416), aortic dissection (MESH:D000784), cancers (MESH:D009369), fibrosis (MESH:D005355), injury to (MESH:D014947), inflammation (MESH:D007249)
- **Chemicals:** Heparan sulfate (MESH:D006497), galunisertib (MESH:C557799), AG490 (MESH:C095512), tofacitinib (MESH:C479163), EGCG (MESH:C045651)
- **Species:** Homo sapiens (human, species) [taxon 9606], Mus musculus (house mouse, species) [taxon 10090]
- **Cell lines:** U87 — Homo sapiens (Human), Glioblastoma, Cancer cell line (CVCL_0022)

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## References

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Source: https://tomesphere.com/paper/PMC11942309