# Cardiometabolic Phenotype in HFpEF: Insights from Murine Models

## TL;DR

This review explores how mouse models help understand the heart condition HFpEF, which is linked to obesity and diabetes.

## Contribution

The paper provides a detailed analysis of murine models to uncover the mechanisms of HFpEF.

## Key findings

- HFpEF is associated with cardiometabolic conditions like obesity and diabetes.
- Murine models reveal pathophysiological aspects such as inflammation and oxidative stress.
- These models can guide the development of new therapies for HFpEF.

## Abstract

Heart failure with preserved ejection fraction (HFpEF) remains a significant challenge in modern healthcare. It accounts for the majority of heart failure cases and their number worldwide is steadily increasing. With its high prevalence and substantial clinical impact, therapeutic strategies for HFpEF are still inadequate. This review focuses on the cardiometabolic phenotype of HFpEF which is characterised by such conditions as obesity, type 2 diabetes mellitus, and hypertension. Various murine models that mimic this phenotype are discussed. Each model’s pathophysiological aspects, namely inflammation, oxidative stress, endothelial dysfunction, changes in cardiomyocyte protein function, and myocardial metabolism alterations are examined in detail. Understanding these models can provide insight into the mechanisms underlying HFpEF and aid in the development of effective therapeutic interventions.