# Prediction of the Atomization Process in Respimat® Soft MistTM Inhalers Using a Volume of Fluid-to-Discrete Phase Model

## TL;DR

This study uses a simulation model to understand how Respimat® inhalers turn liquid into mist, focusing on factors like speed and liquid properties.

## Contribution

A validated VOF-to-DPM model is introduced to simulate and analyze the atomization process in Respimat® inhalers.

## Key findings

- Higher jet inlet velocities produce finer and more uniform droplets but reduce total atomized droplet mass.
- Surface tension reduction has a dual effect, promoting breakup but destabilizing droplet formation.
- Lower viscosity increases ligament breakup but also promotes droplet coalescence, affecting atomization efficiency.

## Abstract

This study investigates the atomization process in Respimat® Soft MistTM Inhalers (SMIs) using a validated Volume of Fluid (VOF)-to-Discrete Phase Model (DPM) to simulate the transition from colliding liquid jets to aerosolized droplets. Key parameters, including colliding jet inlet velocity, surface tension, and liquid viscosity, were systematically varied to analyze their impact on the atomization, i.e., aerosolized droplet size distributions. The VOF-to-DPM simulation results indicate that higher jet inlet velocities enhance ligament fragmentation, producing finer and more uniform droplets while reducing total atomized droplet mass. The relationship between surface tension and atomization performance in colliding jet atomization is not monotonic. Reducing surface tension plays a complex dual role in the atomization process. On the one hand, lower surface tension enhances the likelihood of liquid jet breakup into a liquid sheet, leading to the formation of smaller ligaments under the same airflow conditions and shear forces. This increases the probability of generating more secondary droplets. On the other hand, reduced surface tension also destabilizes the liquid surface shape, decreasing the formation of fine, high-sphericity droplets in regimes where surface tension is a dominant force. Viscosity also influences atomization through complex mechanisms, i.e., lower viscosity reduces resistance to ligament breakup but promotes droplet interactions and coalescence, while higher viscosity suppresses ligament fragmentation, generating larger droplets and reducing atomization efficiency. The validated VOF-to-DPM framework provides critical insights for enhancing the performance and efficiency of inhalation therapies. Future work will incorporate nozzle geometry, jet impingement angles, and surfactant effects to better understand and optimize the atomization process in SMIs, focusing on achieving preferred droplet size distributions and emitted doses for enhanced drug delivery efficiency in human respiratory systems.