# Adolescent Fentanyl Use: Toxicological Risks, Epidemiological Trends, and Public Health Strategies

**Authors:** Matteo Antonio Sacco, Saverio Gualtieri, Agostinho Santos, Bárbara Mendes, Isabella Aquila

PMC · DOI: 10.7759/cureus.79558 · 2025-02-24

## TL;DR

This paper explores the dangers of fentanyl use among adolescents, its rising misuse, and strategies to prevent related deaths.

## Contribution

The study provides insights into fentanyl's toxicological risks and proposes public health strategies to address adolescent misuse.

## Key findings

- Fentanyl's high potency increases overdose risk when combined with alcohol and benzodiazepines.
- Adolescent fentanyl-related deaths have surged due to counterfeit drugs and lack of awareness.
- Prevention requires public education, harm reduction, and policy changes.

## Abstract

Fentanyl has become a critical public health concern due to its increasing presence in illicit drug markets and its role in the rising number of opioid-related fatalities, particularly among adolescents. This study examines the toxicological properties of fentanyl, its accessibility through online platforms, and the behavioral factors contributing to its misuse in adolescent populations. Key findings highlight the high risk of overdose due to fentanyl’s potency, especially when combined with substances such as alcohol and benzodiazepines. Epidemiological data reveal a dramatic surge in adolescent fentanyl-related deaths, exacerbated by counterfeit prescription drugs and a lack of awareness regarding its extreme potency. The study also explores prevention and intervention strategies, including public health education, harm reduction approaches, and policy recommendations aimed at mitigating the growing crisis. Addressing this issue requires a multifaceted approach, integrating medical, social, and legislative efforts to protect vulnerable adolescent populations.

## Linked entities

- **Chemicals:** fentanyl (PubChem CID 3345), alcohol (PubChem CID 702)

## Full-text entities

- **Diseases:** overdose (MESH:D062787), deaths (MESH:D003643)
- **Chemicals:** benzodiazepines (MESH:D001569), Fentanyl (MESH:D005283), alcohol (MESH:D000438)

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Source: https://tomesphere.com/paper/PMC11939030