# Clinical Efficacy of CGF Combined With Periodic Supramolecular Salicylic Acid in the Treatment of Chloasma

## TL;DR

Combining CGF and supramolecular salicylic acid injections significantly improves melasma and skin aging, with high patient satisfaction.

## Contribution

Demonstrates the effectiveness of combining CGF and supramolecular salicylic acid for melasma treatment.

## Key findings

- The total effective rate of treatment was 95%.
- VISIA scores for skin parameters improved significantly after treatment.
- MASI scores decreased significantly, indicating reduced melasma severity.

## Abstract

To investigate the clinical efficacy of CGF combined with supramolecular salicylic acid cycle injection for melasma.

Twenty patients with chloasma admitted to our hospital were selected and treated with CGF facial injection. After each CGF injection, supramolecular salicylic acid was given once. After one cycle of treatment, the severity of melasma and skin parameters before and after treatment were compared using the modified melasma Area and Severity index (MASI) and VISIA facial image analysis system, respectively. At the same time, the patients' self‐satisfaction was investigated.

The total effective rate of CGF combined with supramolecular salicylic acid in the treatment of chloasma was 95%. Compared with before treatment, the VISIA scores in spots, UV spots, brown spots, red areas, wrinkles, texture, pore and porphyrins scores were significantly increased after treatment. After CGF combined with supramolecular salicylic acid treatment, the MASI score of chloasma patients was significantly reduced (4.70 ± 2.47 vs. 15.30 ± 4.01, p < 0.001). The results showed that the total satisfaction of patients with facial skin improvement after CGF combined with supramolecular salicylic acid treatment was 95.00%.

CGF combined with supramolecular salicylic acid has an obvious effect on the comprehensive overall improvement of melasma and facial aging patients, and can effectively accelerate the speed of skin lesion repair and pigment elimination, which is worthy of clinical promotion and application.