Structural connectivity of the fore- and mid-brain in prairie voles
Kyle R. Gossman, Emalee Andrews, Ben Dykstra, Kyle Ta, Arian Ashourvan, Adam S. Smith
TL;DR
This study maps brain connections in prairie voles to better understand how complex social behaviors are processed.
Contribution
The study provides a detailed structural connectivity map of the social decision-making network in prairie voles.
Findings
Many social decision-making network brain regions share bi-directional innervation.
The anterior hypothalamus is identified as a hub in the network.
The Ent and LH show high network connectivity despite being outside the SDMN.
Abstract
Mammals live in complex social systems that require higher order cognition to process and display complex social behaviors. It is suggested that brain networks, such as the social decision-making network (SDMN), have evolved to process such information. Recent functional connectivity studies of the SDMN have revealed distinct network dynamics during different social events across several species. However, the structural mapping of this network is incomplete which limits structural-functional modeling. Here, we assess the structural connectivity of an extended SDMN as well as the fore- and mid-brain afferent projections with the use of cholera toxin subunit-B retrograde tracers and the prairie vole (Microtus ochrogaster), a socially monogamous rodent that displays complex social behaviors. This work greatly expands upon the limited structural connectivity of the vole social brain and…
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Taxonomy
TopicsNeuroendocrine regulation and behavior · Memory and Neural Mechanisms · Primate Behavior and Ecology