Refractory ulcers of both legs with psoriasis vulgaris successfully treated with dehydrated human amnion/chorion membrane: A case report

TL;DR

An 80-year-old man with psoriasis and a stubborn leg ulcer healed successfully using a human amnion membrane product.

Contribution

First documented use of dehydrated human amnion/chorion membrane for treating a venous ulcer in a psoriasis patient.

Findings

Application of dHACM led to substantial wound healing within 4 weeks.

Treatment eliminated the need for skin grafting.

dHACM was effective in a patient with compromised skin defenses due to psoriasis.

Abstract

Patients with psoriasis are particularly susceptible to skin damage and secondary infections due to impaired skin defenses and chronic inflammation. This case report describes an 80-year-old male with psoriasis vulgaris and a refractory venous stasis ulcer that successfully achieved epithelialization following treatment with dehydrated human amnion/chorion membrane (dHACM; EPIFIX®). Despite initial management involving infection control and wound debridement, the ulcer exhibited minimal improvement until the application of dHACM. Within 4 wk, substantial wound contraction and epithelialization were achieved, eliminating the need for skin grafting. The regenerative properties of dHACM, employed in accordance with the TIMERS framework, facilitated effective wound healing through a minimally invasive approach. This case represents the first documented use of dHACM for a venous ulcer in a patient with psoriasis vulgaris, underscoring its potential as an innovative therapeutic option for managing chronic ulcers.

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