# Surgical Consideration in Total Knee Arthroplasty for a Patient With Incidental Femoral Intramedullary Fibrous Dysplasia

**Authors:** Ren Yi Kow, Suraya Zainul-Abidin, Woon Theng Lo, Xiu Fen Chen, Ming Han Lincoln Liow

PMC · DOI: 10.7759/cureus.79528 · 2025-02-23

## TL;DR

This paper discusses a case where a patient with knee osteoarthritis also had an incidental bone condition, requiring special surgical planning to avoid complications during knee replacement.

## Contribution

The paper highlights the surgical challenges and considerations when performing TKA in patients with incidental femoral fibrous dysplasia.

## Key findings

- A long femoral stem was used to prevent periprosthetic fracture due to a stress riser from a bone biopsy.
- The case emphasizes the need for careful planning in managing incidental bone tumors during TKA.
- The patient fully recovered after the surgical intervention.

## Abstract

Fibrous dysplasia (FD) is an uncommon, benign bone disorder caused by a somatic mutation in the GNAS gene on chromosome 20, leading to impaired osteoblastic differentiation and the replacement of normal bone with structurally weak, fibro-osseous tissue. It is typically diagnosed during childhood, though some cases remain undetected until incidentally discovered in adulthood.

We present a patient with symptomatic knee osteoarthritis and an incidental finding of monostotic femur FD. The presence of FD in this anatomical location complicates an otherwise straightforward total knee arthroplasty (TKA). A bone biopsy was performed to rule out malignant transformation of the FD. The resulting bone defect posed a risk of periprosthetic fracture due to the stress riser created by the biopsy. A long femoral stem was used to mitigate this risk, and the patient recovered fully.

This case underscores the critical importance of meticulous planning in managing patients with incidental findings of potential bone tumors. Biopsy site selection must consider definitive surgical management while avoiding pitfalls, such as periprosthetic fractures that may arise from stress risers created by biopsy site fenestration.

## Linked entities

- **Genes:** GNAS (GNAS complex locus) [NCBI Gene 2778]
- **Diseases:** fibrous dysplasia (MONDO:0000845)

## Full-text entities

- **Genes:** GNAS (GNAS complex locus) [NCBI Gene 2778] {aka AHO, AIMAH1, C20orf45, GNAS1, GPSA, GSA}
- **Diseases:** periprosthetic fracture (MESH:D057068), FD (MESH:D005357), Intramedullary (MESH:D013120), benign bone disorder (MESH:D001847), monostotic femur FD (MESH:D005358), knee osteoarthritis (MESH:D020370), bone tumors (MESH:D001859)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11937616/full.md

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Source: https://tomesphere.com/paper/PMC11937616