# The impact of clot permeability on platelet fluxes toward its surface

## TL;DR

This study explores how clot permeability affects platelet movement and adhesion, revealing that permeable clots can significantly increase platelet flux.

## Contribution

The novel contribution is the systematic investigation of platelet transport and adhesion influenced by clot permeability using a finite element model.

## Key findings

- Highly permeable clots can increase platelet flux up to four times compared to non-permeable clots.
- Platelet transport is significantly influenced by clot permeability, reaction rates, and flow conditions.

## Abstract

Platelet aggregation is regulated by a series of chemical reactions that control platelet adhesion on a thrombogenic surface. These reactions are influenced by the complex interaction between reaction kinetics and hemodynamics. This study systematically investigates the transport of platelets, considering the interaction between flow-mediated mass transfer mechanisms and reaction kinetics as a function of clot permeability. A two-dimensional finite element model is developed to replicate static blood flow, platelet transport, and adhesion on a semi-elliptical and semi-circular structure representing permeable clots. The platelet-clot interface interactions are extensively investigated using a hindered transport model, focusing on clot permeabilities, reaction rates, and flow conditions. In the case of clots with highly reactive surfaces, an increase in clot permeability can lead up to four-fold increase in total platelet flux compared to non-permeable clots due to differences in transport environments.